ID   MUTS_ALCBS              Reviewed;         859 AA.
AC   Q0VNJ1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=ABO_1809;
OS   Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 /
OS   SK2).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Alcanivoracaceae; Alcanivorax.
OX   NCBI_TaxID=393595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2;
RX   PubMed=16878126; DOI=10.1038/nbt1232;
RA   Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T., Brecht M.,
RA   Buhrmester J., Chernikova T.N., Denaro R., Ferrer M., Gertler C.,
RA   Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N., Lang S., Linke B.,
RA   McHardy A.C., Meyer F., Nechitaylo T., Puehler A., Regenhardt D., Rupp O.,
RA   Sabirova J.S., Selbitschka W., Yakimov M.M., Timmis K.N., Vorhoelter F.-J.,
RA   Weidner S., Kaiser O., Golyshin P.N.;
RT   "Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium
RT   Alcanivorax borkumensis.";
RL   Nat. Biotechnol. 24:997-1004(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM286690; CAL17257.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0VNJ1; -.
DR   SMR; Q0VNJ1; -.
DR   STRING; 393595.ABO_1809; -.
DR   EnsemblBacteria; CAL17257; CAL17257; ABO_1809.
DR   KEGG; abo:ABO_1809; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000008871; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..859
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335107"
FT   REGION          797..822
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         612..619
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   859 AA;  94598 MW;  AA8FA335C568E1D7 CRC64;
     MTADLSQHTP MMQQYLGIKA EHPDQLVFYR MGDFYELFFG DAQKAARLLD ITLTQRGQSA
     GKPIPMAGIP YHAAENYLAR LVKLGESVAI AEQIGDPALA KGPVERKVVR IVTPGTVSDE
     ALLEERRDNL LCAVFDHNNQ YGCASLDLAA GRFLVTQVEG AEQLQALLER WSPAELLISE
     EHGLPGRWSD RPGTRKRPSW EFDEDAARRQ LCQQFQVQDL AGFGEPSPVA VSAAGALLGY
     AKETQRGELP HITGLTVESF DDAVAMDAAT RRNLELTETL DGQEQHTLAW VLDSTKTAMG
     ARLLKRWVHQ PLRNRTTLTQ RQDQIDALRQ GWCFESARDV LNDIGDMERI LGRVALRSAR
     PRDLTRLHAS LKALPPLIGT LPAADCFCEL IERIGQFPNQ VELLGTAVIE NPPMLIRDGG
     VIAPGYSEEL DELRSISENA GAILVDIETR ERERTQLSTL RVKYNRVHGY YIELSRRESD
     QAPTDYQRRQ TLKNAERFIT PELKEFEDKA LSASSKALAL EKRLYEALLE KVAADLHALQ
     RSAAAVAELD VLASLAERAE ALNWVLPQLV DDEAIIEIVD GRHPVVEQVL DDAFVPNSLH
     LDNARRMVII TGPNMGGKST YMRQTALIAL LAHLGSCVPA ASARIGSLDR IFTRIGSSDD
     LAGGRSTFMV EMSETANILN NATAQSLVLM DEIGRGTSTF DGLSLAWAAA EHLARNLKSF
     TLFATHYFEL TQLPEQLPGI YNAHLTASEH DNRIVFLHRV QEGPASRSYG LQVAQLAGVP
     SSVIHRAGEK LRELEQSKPL APSATPPSSY AAPSPAAAPA QASLFNEPNA IELALTDLDP
     DELTPKQALE ALYTLKKLT