ID   MUTS_ALIF1              Reviewed;         854 AA.
AC   Q5E7G7;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 2.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=VF_0534;
OS   Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Aliivibrio.
OX   NCBI_TaxID=312309;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700601 / ES114;
RX   PubMed=15703294; DOI=10.1073/pnas.0409900102;
RA   Ruby E.G., Urbanowski M., Campbell J., Dunn A., Faini M., Gunsalus R.,
RA   Lostroh P., Lupp C., McCann J., Millikan D., Schaefer A., Stabb E.,
RA   Stevens A., Visick K., Whistler C., Greenberg E.P.;
RT   "Complete genome sequence of Vibrio fischeri: a symbiotic bacterium with
RT   pathogenic congeners.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:3004-3009(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000020; AAW85029.2; -; Genomic_DNA.
DR   RefSeq; WP_011261298.1; NC_006840.2.
DR   RefSeq; YP_203917.2; NC_006840.2.
DR   AlphaFoldDB; Q5E7G7; -.
DR   SMR; Q5E7G7; -.
DR   STRING; 312309.VF_0534; -.
DR   PRIDE; Q5E7G7; -.
DR   EnsemblBacteria; AAW85029; AAW85029; VF_0534.
DR   KEGG; vfi:VF_0534; -.
DR   PATRIC; fig|312309.11.peg.525; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000537; Chromosome I.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..854
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224416"
FT   BINDING         615..622
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   854 AA;  95444 MW;  A2F9CE55F7B5540A CRC64;
     MAIKSTEKHT PMMQQYLRLK SENPDILLFY RMGDFYELFY DDAKRASQLL EISLTKRGSS
     AGEPIPMAGI PYHAVEGYLA KLVQQGESVA ICEQVGDPAT SKGPVERKVV RIVTPGTVTD
     EALLPERFDN LIAAIYHHKG QFGYATLDIT SGRFKVSEPN TEEAMLAELQ RTAPTELLFS
     EDFEPVHLLE KRNGNRRRPV WEFELDTAKQ QLNNQFGTRD LVGFGVEKAE FGLCAAGCLI
     QYVKDTQRTT LPHIRSIIMD HQDDSVILDA ATRRNLEITQ NLAGGFNHTL AEILDHTSTA
     MGSRLLKRWL HQPVRTHDVL NQRLDAIGEL KESGLFADMA PQLKNIGDVE RILARLALRS
     ARPRDLARLR NALQQLPELS QTTQEFQQDH LLTLAASAQP IDSICELLER AIKENPPVVI
     RDGGVLADGY NEELDQWRDL ANGATQYLEK LEQEERERHD IDTLKVGYNN VHGFYIQISK
     GQSHKAPAHY VRRQTLKNAE RYIIPELKEH EDKVLNSKSK ALAIEKRLWE ELFDQLLPHL
     EQLQSMANAI SELDVLSNLA ERADTLNYCR PVLTKETGIN IEGGRHPVVE QVMSDPFIAN
     PIKLNPDRKM LIITGPNMGG KSTYMRQTAL IALMAHVGCY VPADSAEIGT LDRIFTRIGA
     SDDLASGRST FMVEMTETAN ILHNATKHSL VLMDEIGRGT STYDGLSLAW ASAEWLATKI
     NAMTLFATHY FELTELPNLF TGLANVHLDA VEHGDEIAFM HAVQEGAANK SYGLAVASLA
     GVPKSVIKKA KQKLQHLESG QVPVPATSTT VKEEHQLSLI PEISEVEEAL AHVNPDDLTP
     RQALEELYRL KALL