ID   MUTS_ALIFM              Reviewed;         854 AA.
AC   B5FAC8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=VFMJ11_0536;
OS   Aliivibrio fischeri (strain MJ11) (Vibrio fischeri).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Aliivibrio.
OX   NCBI_TaxID=388396;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MJ11;
RA   Mandel M.J., Stabb E.V., Ruby E.G., Ferriera S., Johnson J., Kravitz S.,
RA   Beeson K., Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RT   "Complete sequence of Vibrio fischeri strain MJ11.";
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001139; ACH66619.1; -; Genomic_DNA.
DR   AlphaFoldDB; B5FAC8; -.
DR   SMR; B5FAC8; -.
DR   EnsemblBacteria; ACH66619; ACH66619; VFMJ11_0536.
DR   KEGG; vfm:VFMJ11_0536; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001857; Chromosome I.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..854
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093654"
FT   BINDING         615..622
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   854 AA;  95422 MW;  FE7896C316FE02A9 CRC64;
     MATKSTEKHT PMMQQYLRLK SENPDILLFY RMGDFYELFY DDAKRASQLL EISLTKRGSS
     AGEPIPMAGI PYHAVEGYLA KLVQQGESVA ICEQIGDPAT SKGPVERKVV RIVTPGTVTD
     EALLPERFDN LIAAIYHHKG QFGYATLDIT SGRFKVSEPN TEEAMLAELQ RTAPTELLFS
     EDFEPVHLLE KRNGNRRRPV WEFELDTAKQ QLNNQFGTRD LVGFGVERAE FGLCAAGCLI
     QYVKDTQRTT LPHIRSIIMD HQDDSVILDA ATRRNLEITQ NLAGGFNHTL AEILDHTSTA
     MGSRLLKRWL HQPVRTHDVL NQRLDAIGEL KESGLFADIA PQLKNIGDVE RILARLALRS
     ARPRDLARLR NALQQLPELS QTTQEFQQNH LLTLAASAQP IDSICELLER AIKENPPVVI
     RDGGVLADGY NEELDQWRDL ANGATQYLEK LEQEERERHD IDTLKVGYNN VHGFYIQISK
     GQSHKAPAHY VRRQTLKNAE RYIIPELKEH EDKVLNSKSK ALAIEKRLWE ELFDQLLPHL
     EQLQSMANAI SELDVLSNLA ERADTLNYCR PVLTKETGIN IEGGRHPVVE QVMSDPFIAN
     PIKLNPDRKM LIITGPNMGG KSTYMRQTAL IALMAHVGCY VPADSAEIGT LDRIFTRIGA
     SDDLASGRST FMVEMTETAN ILHNATKHSL VLMDEIGRGT STYDGLSLAW ASAEWLATKI
     NAMTLFATHY FELTELPNLF TGLANVHLDA VEHGDEIAFM HAVQEGAANK SYGLAVASLA
     GVPKSVIKKA KQKLQHLESG QVSVPATSTT VKEEHQLSLI PEISEVEEAL ANVNPDDLTP
     RQALEELYRL KALL