ID   MUTS_ALISL              Reviewed;         855 AA.
AC   B6ENH6;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=VSAL_I0632;
OS   Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain
OS   LFI1238)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Aliivibrio.
OX   NCBI_TaxID=316275;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LFI1238;
RX   PubMed=19099551; DOI=10.1186/1471-2164-9-616;
RA   Hjerde E., Lorentzen M.S., Holden M.T., Seeger K., Paulsen S., Bason N.,
RA   Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S.,
RA   Thurston S., Parkhill J., Willassen N.P., Thomson N.R.;
RT   "The genome sequence of the fish pathogen Aliivibrio salmonicida strain
RT   LFI1238 shows extensive evidence of gene decay.";
RL   BMC Genomics 9:616-616(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; FM178379; CAQ78317.1; -; Genomic_DNA.
DR   AlphaFoldDB; B6ENH6; -.
DR   SMR; B6ENH6; -.
DR   STRING; 316275.VSAL_I0632; -.
DR   EnsemblBacteria; CAQ78317; CAQ78317; VSAL_I0632.
DR   KEGG; vsa:VSAL_I0632; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001730; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR   PROSITE; PS51450; LRR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..855
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093605"
FT   BINDING         615..622
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   855 AA;  95412 MW;  8220B4482851F84B CRC64;
     MAIKSTEKHT PMMQQYLRLK SENPDILLFY RMGDFYELFY DDAKRASQLL EISLTKRGSS
     AGEPIPMAGL PYHAVEGYLA KLVQQGESVA ICEQIGDPAT SKGPVERKVV RIVTPGTVTD
     EALLPERFDN LIAAIYHHKG QFGYATLDIT SGRFKVSEPS TEESMLAELQ RTSPTELLFS
     EDFEPVHLLE KRNGNRRRPV WEFELDTAKQ QLNQQFGTRD LVGFGVENAE FGLCAAGCLI
     QYVKDTQRTT LPHIRSIVMD RQDDSVILDA ATRRNLEITQ NLAGGFNHTL SEVLDHTSTA
     MGSRLLKRWL HQPIRTHDVL NQRLDAIGEL KSNGLYAELS PQLKQIGDVE RILARLALRS
     ARPRDLARLR NALQQLPELA QSTQAFEQTH LLELASLAQP IDSICELLER AVKENPPVVI
     RDGGVLADGY NEELDQWRDL ANGAALFLSK LEQEERERHD IDTLKVGYNN VHGFYIQISK
     GQSHKAPAHY VRRQTLKNAE RYIIPELKAH EDKVLSSKSK ALAIEKKLWE ELFDQLLPHL
     EQLQLMANAI SELDVLSNLA ERADTLNYCR PTLSSDIGMK IEGGRHPVVE QVMSDPFIAN
     PINLNDDRKM LIITGPNMGG KSTYMRQTAL IALMAHVGCY VPADSAHIGL LDRIFTRIGA
     SDDLASGRST FMVEMTETAN ILHNATQHSL VLMDEIGRGT STYDGLSLAW ASAEWLATKI
     NAMTLFATHY FELTELPNLF SGLANVHLDA VEHGDEIAFM HAVQEGAANK SYGLAVASLA
     GVPKAVIKKA KQKLQQLENG QPKNQSLTST QIKQEHQLSL IPEPSEVEEA LAKVNPDDLS
     PRQALEALYR LKALL