ID   MUTS_ALKCK              Reviewed;         871 AA.
AC   Q5WFY3;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=ABC2187;
OS   Alkalihalobacillus clausii (strain KSM-K16) (Bacillus clausii).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=66692;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSM-K16;
RA   Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y.,
RA   Kawai S., Ito S., Horikoshi K.;
RT   "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-
RT   K16.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AP006627; BAD64722.1; -; Genomic_DNA.
DR   RefSeq; WP_011247030.1; NC_006582.1.
DR   AlphaFoldDB; Q5WFY3; -.
DR   SMR; Q5WFY3; -.
DR   STRING; 66692.ABC2187; -.
DR   PRIDE; Q5WFY3; -.
DR   EnsemblBacteria; BAD64722; BAD64722; ABC2187.
DR   KEGG; bcl:ABC2187; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001168; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..871
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224346"
FT   REGION          791..840
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        791..828
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         605..612
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   871 AA;  97424 MW;  F370182D20D87F2A CRC64;
     MAQMHTPMMK QYLQIKAKYQ DAFLFFRLGD FYEMFNEDAI KAAQELEITL TGRGQGEDRI
     PMCGVPYHSA DSYIARLIDK GYKIAICEQV EDPKTAKGVV KREVTKVLTP GTLMNSKLLA
     EKENNYLLAF ASEGEDGWGI ARCDLSTGES DVTLIRGGSA ELLQEIAASG VKEAIAPAGL
     EEELKAKLGE QQGFVVSYEE QEDVPKEYER LINHIQQPLL KRAYGRMLHY LLATQKQSLR
     HLQQVVFHPA DSYLKMDVHA KRNLELVQTL RDKKKSGSLL AVIDQTVTAM GGRLLRQWIE
     RPLVDRKAIA GRQAVVEAFL EHFFEREQLR DCLRQVYDIE RLAARIAYGS VNARELVQLK
     RSLQNIPEIE ATLEQVGLGG RWLNQSEQFA DLVALMEQSL VDDPPLSLTE GGLIVDGYNE
     ELDAYRDASR NGKQWIAELE QSEREATGIR SLKVGYNRVF GYYIEVTRAN AHLLPDGRYE
     RKQTLTNAER YITPELKEKE ALILEADEKL ADLEYRLFAD IRKQVEAYVA SLQKLAADIS
     EMDVLAGFAS VAEQNGYTKP TITESRDVAI KGGRHPVVET VIKRGSYVEN DIDLTGDRDM
     LLITGPNMGG KSTYMRQLAL TVVMAQIGSY VPAAEATLPL FDQIFTRIGA ADDLASGQST
     FMVEMLETKD ALVKATPHSL ILLDEIGRGT STYDGMALAQ AIIEYIYETI GAKTLFSTHY
     HELTRLADSL HTLRNVHVSA VEENGTVVFL HQVIEGAADR SYGVYVAELA GLPKQVTTRA
     EALLTELEHL PQRPTSASVE QPVDSAKTET AATAEEPQQL SLFPTDEETK PKQPTKKERS
     VLAKMAEVDV LHLTPLQALE KINEWQKQLN K