ID   MUTS_ALKEH              Reviewed;         878 AA.
AC   Q0A8K3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Mlg_1485;
OS   Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Alkalilimnicola.
OX   NCBI_TaxID=187272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1101 / DSM 17681 / MLHE-1;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S.,
RA   Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B.,
RA   Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P.;
RT   "Complete sequence of Alkalilimnicola ehrilichei MLHE-1.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000453; ABI56834.1; -; Genomic_DNA.
DR   RefSeq; WP_011629229.1; NC_008340.1.
DR   AlphaFoldDB; Q0A8K3; -.
DR   SMR; Q0A8K3; -.
DR   EnsemblBacteria; ABI56834; ABI56834; Mlg_1485.
DR   KEGG; aeh:Mlg_1485; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001962; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..878
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335108"
FT   REGION          800..842
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          859..878
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   878 AA;  96082 MW;  A83ACF37B64044EE CRC64;
     MAQSSPKASS RHTPMMRQFL RIKAEHPDIL LFYRMGDFYE LFYEDAERAA KLLDITLTTR
     GQSAGEPIPM AGVPVHAVES YLARLVRQGE SVAICEQIGD PDNSKGPVER QVVRIVTPGT
     LTDEALLEER QSNILAALSC HQSRWGLASL ELSSGRFSLT EPADEQALAA DLERLNPAEL
     LVDEALTLPT GLAVGPGLTR RPPWHFELDT ATDLLTEQFG TRDLAGFGAQ DHSAGLAAAG
     ALLQYVRETQ RSALPHIRRL QVEHGDQAIV IDAASRRNLE LERNLSGGTE HTLASVLDST
     VNAMGSRLLR RWLNRPLRDR TTLQARHQAV EILMAESLTE ALRRQLRGIS DVERILARVA
     LGSARPRDLT GLRETLARLP DIQATLTGAG APRLVDLAAQ CGEHPQTLDH LRRALVDQPP
     VVIRDGGVIA EGYDATLDEL RTLSENADNY LLELEQRERE RTGISTLKVG YNRVHGYYIE
     VTRAQADAVP AEYVRRQTLK GVERYILPEL KAFEDKVLSA REKALAREKV LYEQLLASLA
     SDLAPLQDTA AALAELDTLA AFAERAQALD YSRPELRDGA GLRIEAGRHP VVEYSLDGPF
     VPNDLTLDDR RRMLIITGPN MGGKSTYMRQ VALITLMAHI GSFVPARAAS LGPVDRIFTR
     IGASDDLAGG RSTFMVEMTE TANILHNATA QSLVLMDEIG RGTSTFDGLA LAWATAERLA
     RDQRAYTLFA THYFEMTALP EQCPGASNVH LDAVEHGERI VFLHAVKPGP ASQSYGLQVA
     ALAGVPGPVL EAAREKLRAL EEESSRQRAE PDQLSLFAEP APPPPLPSAA EQALSEVDPD
     ELSPRQALDL LYRLKALTSG EEGADKKARG DAVDARSR