ID   MUTS_ALKHC              Reviewed;         865 AA.
AC   Q9KAC0;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BH2369;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; BA000004; BAB06088.1; -; Genomic_DNA.
DR   PIR; A83946; A83946.
DR   RefSeq; WP_010898523.1; NC_002570.2.
DR   AlphaFoldDB; Q9KAC0; -.
DR   SMR; Q9KAC0; -.
DR   STRING; 272558.10174989; -.
DR   EnsemblBacteria; BAB06088; BAB06088; BAB06088.
DR   KEGG; bha:BH2369; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..865
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115069"
FT   REGION          814..833
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         605..612
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   865 AA;  98368 MW;  A00D4346163DE51C CRC64;
     MALQTPMMKQ YLEIKAQYKD AFLFFRLGDF YELFLDDAVK AAQELEITLT GRGKGEERIP
     MCGVPYHSAD HYISRLLEKG YKIAICEQVE DPKNAKGVVK REVIKLITPG TIMDGKLIVE
     KENNFLCAVT RFEDQSYGIA RADLTTGESR VSLVSEQDDL FHELASSSIK EVVLSPGWTE
     EDAHRLRQSL SVTLSEEEAE DLPKGYESLC ENVEQPKLLR AFGRLLQYLL RTQKRSLEHL
     QPVQYDPPNE VMKIDLHSRR NLELVETLRE KKKKGSLLWA VDETVTAMGG RLLKQWVERP
     LLSKKEIERR QGLVQSFLDH YFEREELRDE LRHVYDLERL VGKVAYGNVN ARELVQLRKS
     LQRIPAIFAL VEKIGNQDVN ERLQTIDRCE SLVDLLEHSL VDDPPVSIKE GGMIRDGFHK
     ELDTYRDASR NGKSWIAELE QKEREATGIK SLKIGYNKVF GYYIEVTKAN IHLLEEGRYE
     RKQTLTNAER YVTPELKEKE ALILNAEESI VQLEYDLFLQ VREQVKDYIR PLQALAQMIS
     ELDVIQGFAT VSETHHYVRP ALQEDRAIAI KGGRHPVVER VIPNGEYVAN DVDMKDGRSI
     LLITGPNMAG KSTYMRQLAL IAIMGQIGCF VPADEARLPI FDQVFTRIGA ADDLASGQST
     FMVEMLETKY ALQKATQNSL ILLDEIGRGT STYDGMALAQ AIIEYIHDEI RAKTLFSTHY
     HELTALEKEL SDVKNVHVSA VEEQGTVVFL HKVVDGQADR SYGIYVAELA GLPNVVTERA
     ETLLAELEGE KEIVASEKEV ASTNEPTQLS LFEPEPLEAY KPKGNKQPLS DEEKTVLHDL
     QSVDVLNTTP LEAIRLLNQW QQKLR