ID   MUTS_ALKMQ              Reviewed;         880 AA.
AC   A6TR79;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Amet_2544;
OS   Alkaliphilus metalliredigens (strain QYMF).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Alkaliphilus.
OX   NCBI_TaxID=293826;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=QYMF;
RX   PubMed=27811105; DOI=10.1128/genomea.01226-16;
RA   Hwang C., Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina Del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F.,
RA   Land M.L., Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J.,
RA   Richardson P., Fields M.W.;
RT   "Complete genome sequence of Alkaliphilus metalliredigens strain QYMF, an
RT   alkaliphilic and metal-reducing bacterium isolated from borax-contaminated
RT   leachate ponds.";
RL   Genome Announc. 4:0-0(2016).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000724; ABR48697.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6TR79; -.
DR   SMR; A6TR79; -.
DR   STRING; 293826.Amet_2544; -.
DR   PRIDE; A6TR79; -.
DR   EnsemblBacteria; ABR48697; ABR48697; Amet_2544.
DR   KEGG; amt:Amet_2544; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001572; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..880
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000071270"
FT   BINDING         624..631
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   880 AA;  99555 MW;  2336DFC3A8872F07 CRC64;
     MANLTPMMQQ YFDIKKQYPD SLLFFRMGDF YELFFQDAET ASRELEITLT GRSCGLEERA
     PMCGVPHHAA TGYIDRLVSN GYKVAICEQI EDVSQAKGIV KRDVVRVITP GTLIDTQLLD
     DKKNNYLMSV FGSRTGFGLA YVDISTGDLF ATEIKENIHP QMLIDEMGRV LPQELLYFIE
     TDKEDPTIIS MIKKRFDFYT NGYEEWSYED TFALNQIKDH FNVVSLEGLG FHPSHLGINA
     AGALFHYLKT TQKRALEHIN HINVYSIHEK MTLDINTRKN LELTETIRSK SKKGSLLGVL
     DKTSTAMGGR MLRKWIEAPL IDPVIINKRL EAVQLLKEQI ELRQELKESL KKIYDLERLA
     GKISYGSVTP RDLIALKNSL SYLPSIINGL EKIQGETFQS LVQSIDPLDE VHSLVELSIL
     EDAPLSSKDG GIIQEGYHKE VDELKNASTE GRQWIAQLEQ KERVNSGIKS LKIKYNKIFG
     YYIEITKSNL SMVPTEYIRK QTLANCERYV TPELKEIESK ILGAEEKVIL LEYHLFIEVR
     EKIAHEITRI QQTARAIAEL DVLYSFAEIA AENNFIKPHI NTSNEIKIVE GRHPVVELTF
     NKESFVPNDT YMDNRDCSMS IITGPNMAGK STYMRQVALI VLMAQIGSFV PASEASIGIV
     DRIFTRIGAS DDLAQGHSTF MVEMSEMANI LNNATANSLV ILDEIGRGTS TFDGLSIAWA
     VIEYMQQYKK SKTLFSTHYH ELTELEGKIQ GVKNYNILVE EDGEEIVFLR KVVSGSTSKS
     YGIQVAKLAG LPLNTLIRAQ EILSDLEKKN NEIKIPAEEE IALSRESEGN SRDTNGIQLD
     LTSFSYNEII EDIRSLNLLE TTPMTAMNLL YQLQKRISSL