ID   MUTS_ALKOO              Reviewed;         880 AA.
AC   A8MFD4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Clos_1554;
OS   Alkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain
OS   OhILAs)).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Alkaliphilus.
OX   NCBI_TaxID=350688;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OhILAs;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Stolz J.F., Dawson A., Fisher E.,
RA   Crable B., Perera E., Lisak J., Ranganathan M., Basu P., Richardson P.;
RT   "Complete genome of Alkaliphilus oremlandii OhILAs.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABW19097.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000853; ABW19097.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; A8MFD4; -.
DR   SMR; A8MFD4; -.
DR   STRING; 350688.Clos_1554; -.
DR   EnsemblBacteria; ABW19097; ABW19097; Clos_1554.
DR   KEGG; aoe:Clos_1554; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   Proteomes; UP000000269; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..880
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335109"
FT   BINDING         625..632
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   880 AA;  99645 MW;  3AF861BF54D7F2A1 CRC64;
     MRKLTPMMQQ YMEIKNQYKD ALMFFRLGDF YELFFDDAET ASRELEITLT ARDCGLESKA
     PMCGVPYHAA NGYIDKLVSK GYKVAICEQV EDPSVAKGIV KRDVVRVITP GTLIDTNLLE
     DKKNNYLVSL YMSSLGCGFS YVDISTGELL STEIVGTSIE QNLIDEISKI EPNELIYFVE
     EEDKIGTNFI EGIRKKLNIH ISKYDPWTFE ESYAMNQIKN QFNILTVESL GFSLNHLGIN
     ATGALIHYLK STQKRTLSHI NKINIYTFTE KMVLDISTRR NLELTETIRG KNKKGSLLWI
     LDKTQTAMGG RMIRKWIEEP LLNIQNINRR LEAVATLKND ILLRCELKES LKQIYDLERL
     SGKIAFGSAT PRDLVALKKS VAFLPDIKKL FENENSGLLK ELLNNIDTLE DIQALIESSI
     LDEPSISLKD GGIIKEGYND ELDELYVAAR EGKHWIAKLE QAEKDRTGIK SLKVGYNKIF
     GYYIEITKSN LHLAPENYIR KQTLANCERY ITPELKELED KILGAEEKSI AIEYEQFIEI
     RNMLLHEIER IQRTARAVAE LDVLYSFAEA ASENNYVKPT VNSSETIDIK EGRHPVVEKV
     LENNMFISND TYINTEDEQL LMITGPNMAG KSTYMRQVAL IILMAQIGSF VPATSATIGI
     TDRIFTRVGA NDDLSQGQST FMVEMSEMAT IVNLATKKSL LIVDEIGRGT STFDGLSIAW
     STAEYICQSL GSRTLFSTHY HELTKLSETY RGIKNYKVLV KEDKEDVIFL HKVVKGNADR
     SYGIQVAKLA GLPAAIITRA SHILSDLERE SIQKEQYIIE STAENTLTAS TDVANEKQLK
     LDDFIESEIV KDLKKINLLE TTPMDALNIL YQLQKKVAEI