ID   MUTS_ANAD2              Reviewed;         882 AA.
AC   B8JA66;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=A2cp1_2247;
OS   Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=455488;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-1 / ATCC BAA-258;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA   Beliaev A.S., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-1.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001359; ACL65585.1; -; Genomic_DNA.
DR   RefSeq; WP_012633423.1; NC_011891.1.
DR   AlphaFoldDB; B8JA66; -.
DR   SMR; B8JA66; -.
DR   EnsemblBacteria; ACL65585; ACL65585; A2cp1_2247.
DR   KEGG; acp:A2cp1_2247; -.
DR   HOGENOM; CLU_002472_3_1_7; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000007089; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..882
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000192193"
FT   BINDING         627..634
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   882 AA;  94954 MW;  7CB7876DB615FB9F CRC64;
     MPEIAQAHTP MMRQYLETKA RYPDAILFFR LGDFYEMFFE DALTASEALQ ITLTARSKGD
     DKVPMCGVPY HAARGYVARL LEKGFKVAIC DQVEEPGKSQ LVKREVTRVV TPGMVLDDQV
     LDPREASWLG AVALEDGRAG LALLDASTGQ LQCGEVDGDE RLVDELRRAG VRELVFSSAA
     DGARTDAIAR AAGAPAARRD AAEFDRAEDR LRKHLGVPSL DGFGVSGLPL GLAAAAAALA
     YLADTQRATP RHVDRISRLS TDDVLLLDEA TRTNLELERT LSGGRKKGTL LALLDRTVTA
     PGGRRLAEWL RYPLTDLARI GARLDAVEEL TGAAVAREEL ALALRPVADL ERLLSRLVLG
     QGNARDLRAL AGALLALPAL AGVLEARGAA RLREAGARLR GLEALAAHLD AAVAEEPPAT
     LREGGFIRRG HSAELDEIVA IAEDGKGWIA AMEAKERERT GIGSLKVRFN KVFGYYLEVT
     KPNLHLVPKD WERRQTTVGG ERFVTPELKT FEEKVLTAEE RRAALEERLF EALRQAVAAE
     APRVRTAADA VATADALLSL SRVAAERGYV RPEVDASEAL EIVDGRHPVV EAVLPDGPAA
     YVPNDVLVAS RGAPECGEHG ALLVITGPNM AGKSTVMRQA ALVVLLAQMG AFVPARRARI
     GLVDRIFTRV GASDDLARGR STFMVEMTET AAILHNATRR SLVVLDEIGR GTSTFDGVSI
     AWAVAEHLHD VTGCRTLFAT HYHELQDLAR ERPAVRNLTV AVREVGDRVV FLRKLVQGGA
     SRSYGIEVAK LAGLPAEVLA RAREILKNLE AMEVDEGGHP ALARGRRRRA GPSAAQLGLF
     GGGAPADPAA EDVAKAIRAI DLDALRPLDA LNLLAGWKKS LE