ID   MUTS_ANADE              Reviewed;         882 AA.
AC   Q2IIJ3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Adeh_1698;
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R.,
RA   Gilna P., Kiss H., Schmutz J., Larimer F., Land M., Kyrpides N.,
RA   Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R.,
RA   Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000251; ABC81471.1; -; Genomic_DNA.
DR   RefSeq; WP_011420754.1; NC_007760.1.
DR   AlphaFoldDB; Q2IIJ3; -.
DR   SMR; Q2IIJ3; -.
DR   STRING; 290397.Adeh_1698; -.
DR   EnsemblBacteria; ABC81471; ABC81471; Adeh_1698.
DR   KEGG; ade:Adeh_1698; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_7; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001935; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..882
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335111"
FT   BINDING         627..634
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   882 AA;  94778 MW;  01F0414426C741F7 CRC64;
     MPEIAQAHTP MMRQYLETKA RYPDAILFFR LGDFYEMFFE DALTASEALQ ITLTARSKGD
     DKVPMCGVPY HAARGYVARL LEKGFKVAIC DQVEEPGKSQ LVKREVTRVV TPGMVLDDQV
     LDPREASWLG AVALEGGRAG LALLDASTGQ LQCGEVDGDE RLVDELRRAG VRELVFSSAA
     DGARTEAIAR AVGAPAARRD AAEFERAEDR LRKHLGVPSL DGFGVSGLPL GLSAAAAALA
     YLADTQRAAP RHVDRISRLS TDDVLLLDEA TRTNLELERT LSGGRKKGTL LALLDRTVTA
     PGGRRLAEWL RYPLADLARI GARLDAVEEL SGASVAREEL AGALRPVADL ERLLSRLVLG
     QGNARDLRAL AGALLALPAL ADVLEARGAA LLREAGGRLR GLEALAAHLD AAVAEEPPAT
     LREGGFIRRG HSAELDEIVA ISEDGKGWIA GLEAKERERT GIGSLKVRFN KVFGYYLEVT
     KPNLHLVPKD WERRQTTVGG ERFVTPELKG FEEKVLTAEE RRAALEERLF EALRQAVAAE
     APRVRTAADA VATADALLSL ARVAAERGYV RPEVDASEAL EIVDGRHPVV EAVLPDGPAA
     YVPNDVLVAS RGAPECAEHG ALLVITGPNM AGKSTVMRQA ALVVLLAQMG AFVPARRARI
     GLVDRIFTRV GASDDLARGR STFMVEMTET AAILHNATRR SLVVLDEIGR GTSTFDGVSI
     AWAVAEHLHD VTGCRTLFAT HYHELQDLAR ERPAVRNLTV AVREVGDRVV FLRKLVQGGA
     SRSYGIEVAK LAGLPAEVLA RAREILKNLE AMEVDEGGHP ALARGRRRRA GPAAAQLGLF
     GGGAAADPAA DEVAKAIRAL DLDALRPLDA LNLLAGWKRS LE