ID   MUTS_ANADF              Reviewed;         882 AA.
AC   A7HC64;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=Anae109_2107;
OS   Anaeromyxobacter sp. (strain Fw109-5).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter;
OC   unclassified Anaeromyxobacter.
OX   NCBI_TaxID=404589;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fw109-5;
RX   PubMed=25614562; DOI=10.1128/genomea.01449-14;
RA   Hwang C., Copeland A., Lucas S., Lapidus A., Barry K., Glavina Del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D.C.,
RA   Detter J.C., Han C.S., Schmutz J., Larimer F.W., Land M.L., Hauser L.J.,
RA   Kyrpides N., Lykidis A., Richardson P., Belieav A., Sanford R.A.,
RA   Loeffler F.E., Fields M.W.;
RT   "Complete genome sequence of Anaeromyxobacter sp. Fw109-5, an anaerobic,
RT   metal-reducing bacterium isolated from a contaminated subsurface
RT   environment.";
RL   Genome Announc. 3:0-0(2015).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000769; ABS26310.1; -; Genomic_DNA.
DR   RefSeq; WP_012096890.1; NC_009675.1.
DR   AlphaFoldDB; A7HC64; -.
DR   SMR; A7HC64; -.
DR   STRING; 404589.Anae109_2107; -.
DR   EnsemblBacteria; ABS26310; ABS26310; Anae109_2107.
DR   KEGG; afw:Anae109_2107; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_7; -.
DR   OMA; MQCGDFY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000006382; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..882
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335112"
FT   BINDING         626..633
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   882 AA;  95275 MW;  AC3637F598636A38 CRC64;
     MPEIAQPTPM MRQYLETKAR YPDALLFFRL GDFYELFFED ALTASEALQI TLTARAKGDD
     KVPMCGVPHH AARGYVARLL EKGFKVAICD QVEEPGKSAI VKREVTRVVT PGMVFDDQVL
     DPREASYLGV VALAEGRAGL ALLDASTGQL QCGEVPDDAR AVDELRRAGV RELVLPLGAD
     AARAERIERA VGVPAARRPA ADYERADDRL RRHLGVASLD GFGVGGEPLG LAAAAAALAY
     LADTQRATPR HVDRVSRLRT EDVLLLDEAT RTNLELERTL NGGRKKGSLL ALLDRSVTAP
     GGRRLAEWLR YPLTELAPIH ARLDAVEELA GASVAREDLA AALRPVADAE RLLSRLVLGQ
     GNARDLRALA GALLALPALA ELLGGRAAAL LRDAGEGTRG LEELAAHLDR AVAEEPPATL
     REGGIIRRGF SPELDEIVAV AEDGKGFIAR LEAREKERTG IGSLKVRFNK VFGYYLEVTK
     ANLHAVPSDY ERRQTTVGGE RFVTPELKRF EETVLTAEER RIAVEGRLFE ELRQRVAEAA
     PRIRTAADAV ATADALLALA RVAAERGYCR PEVDGSEVLE IVDGRHPVVE AVLPEGPAGF
     VPNDVLVASR GALECERLGA LHVITGPNMA GKSTVMRQAA LVTLLAQMGA FVPARKARVG
     IVDRIFTRVG ASDDLARGRS TFMVEMTETA AILHNATRRS LVVLDEIGRG TSTFDGVSIA
     WAVAEHLHDQ VGCRTLFATH YHELQDLARE RPAVRNLTVA VREVGDRVVF LRKLVQGGAS
     RSYGIEVAKL AGLPAEVLAR AREILKNLEA LEVDEGGHAA LARGRKTRRA DPQSQLGLFA
     PAPAPADPAL EEIASALRAT EIDALRPLDA LNLLAAWRAK LR