ID   MUTS_ANAPZ              Reviewed;         820 AA.
AC   Q2GJL7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=APH_0857;
OS   Anaplasma phagocytophilum (strain HZ).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Anaplasma; phagocytophilum group.
OX   NCBI_TaxID=212042;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HZ;
RX   PubMed=16482227; DOI=10.1371/journal.pgen.0020021;
RA   Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V.,
RA   Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M.,
RA   Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N., Nelson W.C.,
RA   Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J.P., Daugherty S.C.,
RA   Davidsen T., Durkin A.S., Gwinn M.L., Haft D.H., Selengut J.D.,
RA   Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R.,
RA   Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H.;
RT   "Comparative genomics of emerging human ehrlichiosis agents.";
RL   PLoS Genet. 2:208-222(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000235; ABD43661.1; -; Genomic_DNA.
DR   RefSeq; WP_011450950.1; NC_007797.1.
DR   AlphaFoldDB; Q2GJL7; -.
DR   SMR; Q2GJL7; -.
DR   STRING; 212042.APH_0857; -.
DR   EnsemblBacteria; ABD43661; ABD43661; APH_0857.
DR   GeneID; 56368815; -.
DR   KEGG; aph:APH_0857; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001943; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..820
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335113"
FT   BINDING         615..622
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   820 AA;  91110 MW;  9C175025BC504CF9 CRC64;
     MSNNTEYTPV LRQYRALKEQ YGECLLLYRL GDFYELFFED AVIASKTLNI VLTKRGTDTP
     MCGVPYHSSE SYIGRLVKSG YKVAVCEQIE TAEEARKRSV RALVRREVTR IVTPGTLVED
     SLLDAKENNY LACISNIGER YGVAWMELST GLFHVRASKL EDLDSEIQRL GPSELLISDK
     LKEQQSMELV LKRHRCAITS HNESFFDSKR AEKVLCGVYG VTTVQGLGDF EEVEVSACGS
     LLEYVRMTQR GSLPKLSYPK VRDSNSFVLI DGPALRNLEL FSTQSGEKKG SLISTIDHTV
     TAMGSRMLKR YLAFPVACHN VINGRQDAVE FFVSNRSLCE VIRGVINGFP DIERILTRVK
     FSKCSPKDIH LLGRALSKIF ELSRIISRST HAIISKILVS LGDHRDLLKL ISEVMLENNA
     TITKDGGFIN PGCNERLAEL ARIQNDSGVL IQRLRDKYRA LTGISSLKIL SNNLLGYYIE
     VSSSYKVSDE SFVRRQSLAN STRYTTAELK ELEERIVSAQ SESADLEAQI FKGLCSRIAD
     ECQDIGLAAE AVAELDVLTT LAEVAVENNY VRPIVDDSKQ FKIVRGRHPV VEVGTDFIAN
     DCDLSEGNSM SLITGPNMAG KSTFLRQNAL IAVLAHIGSF VPAEHAHIGV IDKIFSRVGA
     SDNIALGHST FMVEMVETAA ILNQATSKSL VILDEIGRGT AINDGLSIAL AAIEHIHDVT
     KSRAICATHY HELPKLSSHF ENIRFFCLRI EEWKGEVVFL HELIPGISSR SYGIHVAGLA
     GFPKGALERA KFFMSKFDEA EHYRSIDSID ITSGRHITDE