ID   MUTS_ANASK              Reviewed;         882 AA.
AC   B4UCY7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=AnaeK_2157;
OS   Anaeromyxobacter sp. (strain K).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter;
OC   unclassified Anaeromyxobacter.
OX   NCBI_TaxID=447217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikiva G.,
RA   Beliaev A.;
RT   "Complete sequence of Anaeromyxobacter sp. K.";
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001131; ACG73384.1; -; Genomic_DNA.
DR   RefSeq; WP_012526185.1; NC_011145.1.
DR   AlphaFoldDB; B4UCY7; -.
DR   SMR; B4UCY7; -.
DR   EnsemblBacteria; ACG73384; ACG73384; AnaeK_2157.
DR   KEGG; ank:AnaeK_2157; -.
DR   HOGENOM; CLU_002472_3_1_7; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001871; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..882
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093606"
FT   BINDING         627..634
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   882 AA;  94953 MW;  81048CF0A64AF96A CRC64;
     MPEIAQAHTP MMRQYLETKA RYPDAILFFR LGDFYEMFFE DALTASEALQ ITLTARSKGD
     DKVPMCGVPY HAARGYVARL LEKGFKVAIC DQVEEPGKSQ LVKREVTRVV TPGMVLDDQV
     LDPREASWLG AVALDDGRAG LALLDASTGQ LQCGEVDGDE RLVDELRRAG VRELVFSSAA
     DGARAEAIAR AVGAPAARRD AAEFERAEDR LRKHLGVPSL DGFGVSGLPL GLAAAAAALA
     YLADTQRAAP RHVDRISRLS TDDVLLLDEA TRTNLELERT LSGGRKKGTL LALLDRTVTA
     PGGRRLAEWL RYPLTDLARI GARLDAVEEL TGAAVAREEL ALALRPVADL ERLLSRLVLG
     QGNARDLRAL AGALLALPAL AAVLEARGAA RLREAGARLR GLEALAAHLD AAVAEEPPAT
     LREGGIIRRG HSAELDEIVA IAEDGKGWIA ALEAKERERT GIGSLKVRFN KVFGYYLEVT
     RPNLHLVPKD WERRQTTVGG ERFVTPELKT LEEKVLTAEE RRAALEERLF EALRQAVAAE
     APRVRTAADA VATADALLSL SRVAAERGYV RPEVDASEAL EIVDGRHPVV EAVLPDGPAA
     YVPNDVLVAS RDAPECAEHG ALLVITGPNM AGKSTVMREA ALVVLLAQMG AFVPARRARI
     GLVDRIFTRV GASDDLARGR STFMVEMTET AAILHNATRR SLVVLDEIGR GTSTFDGVSI
     AWAVAEHLHD VTGCRTLFAT HYHELQDLAR ERPAVRNLTV AVREVGDRVV FLRKLVQGGA
     SRSYGIEVAK LAGLPAEVLA RAREILKNLE AMEVDEGGHP ALARGRRRRA GPSAAQLGLF
     GGGAAADPAA EEVAKAIRAI DLDALRPLDA LNLLAGWKKS LE