ID   MUTS_AQUAE              Reviewed;         859 AA.
AC   O66652;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=DNA mismatch repair protein MutS;
GN   Name=mutS; Synonyms=mutS1; OrderedLocusNames=aq_308;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AE000657; AAC06613.1; -; Genomic_DNA.
DR   PIR; H70327; H70327.
DR   RefSeq; NP_213212.1; NC_000918.1.
DR   RefSeq; WP_010880150.1; NC_000918.1.
DR   AlphaFoldDB; O66652; -.
DR   SMR; O66652; -.
DR   STRING; 224324.aq_308; -.
DR   EnsemblBacteria; AAC06613; AAC06613; aq_308.
DR   KEGG; aae:aq_308; -.
DR   PATRIC; fig|224324.8.peg.250; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_0; -.
DR   InParanoid; O66652; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..859
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115063"
FT   BINDING         607..614
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   859 AA;  98366 MW;  D346E0853D8DD7D7 CRC64;
     MEKSEKELTP MLSQYHYFKN QYPDCLLLFR LGDFYELFYE DAYIGSKELG LVLTSRPAGK
     GKERIPMCGV PYHSANSYIA KLVNKGYKVA ICEQVEDPSK AKGIVKREVV RVITPGTFFE
     RDTGGLASLY KKGNHYYVGY LNLAVGEFLG AKVKIEELLD LLSKLNIKEI LVKKGEKLPE
     ELEKVLKVYV SELEEEFFEE GSEEILKDFG VLSLQAFGFE EDTYSLPLGA VYKYAKTTQK
     GYTPLIPRPK PYRDEGFVRL DIKAIKGLEI LESLEGRKDI SLFKVIDRTL TGMGRRRLKF
     RLLSPFRSRE KIERIQEGVQ ELKENREALL KIRQILEGMA DLERLVSKIS SNMATPRELV
     YLKNSLKKVE ELRLLLLELK APIFKEILQN FEDTKKIIND IEKTLVEDPP LHVKEGGLIR
     EGVNAYLDEL RFIRDNAETY LREYEKKLRQ ETGIQSLKIG YNKVMGYYIE VTKPNLKYVP
     SYFRRRQTLS NSERFTTEEL QRLEEKILSA QTRINDLEYE LYKELRERVV KELDKVGNNA
     SAVAEVDFIQ SLAQIAYEKD WAKPQIHEGY ELIIEEGRHP VIEEFVENYV PNDTKLDRDS
     FIHVITGPNM AGKSSYIRQV GVLTLLSHIG SFIPARRAKI PVVDALFTRI GSGDVLALGV
     STFMNEMLEV SNILNNATEK SLVILDEVGR GTSTYDGIAI SKAIVKYISE KLKAKTLLAT
     HFLEITELEG KIEGVKNYHM EVEKTPEGIR FLYILKEGKA EGSFGIEVAK LAGLPEEVVE
     EARKILRELE EKENKKEDIV PLLEETFKKS EEAQRLEEYE EIIKKIEEID IGNTTPLQAL
     LILAELKKKC SFSKKESGA