ID   MUTS_AQUPY              Reviewed;         855 AA.
AC   P70755;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutS;
GN   Name=mutS;
OS   Aquifex pyrophilus.
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=2714;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Wetmur J.G., Rosenfeld A., Wong D.M.;
RT   "Hyperthermophilic MutS proteins: isolation, characterization and
RT   enhancement of PCR specificity.";
RL   Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; U71154; AAB16998.1; -; Genomic_DNA.
DR   AlphaFoldDB; P70755; -.
DR   SMR; P70755; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..855
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115064"
FT   BINDING         607..614
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   855 AA;  97656 MW;  5AA8C8EEEE234E8A CRC64;
     MGKEEKELTP MLAQYHQFKS MYPDCLLLFR LGDFYELFYE DAVVGSKELG LVLTSRPAGK
     GRERIPMCGV PYHSANNYIA KLVNKGYKVA ICEQVEDPSK AKGIVKRDVI RVITPGTFFE
     RETGGLCSLY RKGKSYLVSY LNLSVGEFIG AKVKEEELID FLSKFNIREV LVKKGEKLPE
     KLEKVLKLHI TELEEEFFEE GKEELLKDYG VPSIKAFGFQ DEDLSLSLGA VYRYAKATQK
     SFTPLIPKPK PYVDEGYVKL DLKAVKGLEI TESIEGRKDL SLFKVVDRTL TGMGRRRLRF
     RLLNPFRSIE RIRKVQEAVE ELINKREVLN EIRKTLEGMS DLERLVSRIS SNMASPRELI
     HLKNSLRKAE ELRKILSLLD SEIFKEIEGS LLNLNKVADL IDKTLVDDPP LHVKEGGLIK
     PGVNAYLDEL RFIRENAEKL LKEYEKKLKK ETGIQSLKIG YNKVMGYYIE VTKANVKYVP
     EHFRRRQTLS NAERYTTEEL QRLEEKILSA QTRINELEYE LYRELREEVV KELDKVGNNA
     TLIGEVDYIQ SLAWLALEKG WVKPEVHEGY ELIIEEGKHP VIEEFTKNYV PNDTKLTEEE
     FIHVITGPNM AGKSSYIRQV GVLTLLAHTG SFLPVKSARI PLVDAIFTRI GSGDVLALGV
     STFMNEMLDV SNILNNATKR SLIILDEVGR GTSTYDGIAI SKAIVKYISE KIGAKTLLAT
     HYLELTELER KVKGVKNYHM EVEETDEGIR FLYILKEGRA KGSFGIDVAK LAGLPEEVVR
     EAKKILKELE GEKGKQEVLP FLEETYKKSV DEEKLNFYEE IIKEIEEIDI GNTTPVKALL
     ILAELKERIK SFIKR