ID   MUTS_AROAE              Reviewed;         879 AA.
AC   Q5NYP9;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=AZOSEA36900;
GN   ORFNames=ebA6453;
OS   Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales;
OC   Rhodocyclaceae; Aromatoleum.
OX   NCBI_TaxID=76114;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EbN1;
RX   PubMed=15551059; DOI=10.1007/s00203-004-0742-9;
RA   Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F.,
RA   Reinhardt R.;
RT   "The genome sequence of an anaerobic aromatic-degrading denitrifying
RT   bacterium, strain EbN1.";
RL   Arch. Microbiol. 183:27-36(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CR555306; CAI09815.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5NYP9; -.
DR   SMR; Q5NYP9; -.
DR   STRING; 76114.ebA6453; -.
DR   EnsemblBacteria; CAI09815; CAI09815; ebA6453.
DR   KEGG; eba:ebA6453; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000006552; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..879
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224344"
FT   BINDING         639..646
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   879 AA;  95162 MW;  04D82C4FEF7A8509 CRC64;
     MGMSEIAKAA QKDKAIGGAD RDSHTPMMQQ YLRIKAQHPD TLLFYRMGDF YELFFDDAEK
     AARLLDITLT TRGQSAGTPI RMAGVPFHAV EQYLARLVKL GESVVIAEQV GEPGATKGPM
     ERAVSRIVTP GTLTDAALLD DRIDSLLLAA TLHRGVLGLA WLNLANGDLR VMECPAEQLQ
     AQFERLRPAE VLVPDGLALP LVESLSPVLR RLADWQFDAG NGERLLTAHF GTRDLAGFDA
     EGLPVALAAA AALFEYARST QRQSLEHVTG LRVEREAEYL RLDAATRRNL ELTETLRGEA
     SPTLFSLLDS CITSMGSRWL RHALHHPLRD RGVAAQRHGA VGELAGSDAG APADIGDARM
     LGAVRAALRG VADVDRITAR IALRSARPRD LAALSDSLAR LPQLHAALGT PQAPLLCDLL
     AAIAVPDNAL DLLVRAVAAE PAAAVRDGGV IAPGFDAELD ELRGIQSNCG EFLLALEVRE
     RERSGIATLK VEFNKVHGFY IEVSHANTGK VPDDYRRRQT LKNAERYITP ELKAFEDKAL
     SAQERALARE KLLYEALLEA LAAHIPALQR IARALACLDG LGAFAEAAVR HSYVCPQFSA
     QPGVDIIGGR HPVVERQVED FISNNCRLAP TRRMLLITGP NMGGKSTFMR QVALIALLAH
     VGAFVPARSA RLGPLDAIFT RIGASDDLAS GRSTFMVEMT EASAILHGAT EQSLVLMDEI
     GRGTSTFDGL ALAFAIARHL LEKNRCLTLF ATHYFELTRL NGDYPECANV HLDAVEHAHR
     IVFLHAVEDG PASQSYGIEV AALAGIPGSV VREAKRRLRA LENREVGNGP QADLFAALPD
     REPATPSHPA LTALAELDPD TLSPREALER LYALKRMTA