ID   MUTS_AZOC5              Reviewed;         931 AA.
AC   A8I275;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=AZC_4714;
OS   Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG
OS   6465 / NBRC 14845 / NCIMB 13405 / ORS 571).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Xanthobacteraceae; Azorhizobium.
OX   NCBI_TaxID=438753;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 / NCIMB
RC   13405 / ORS 571;
RA   Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T.,
RA   Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B.,
RA   Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H.;
RT   "Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium
RT   caulinodans ORS571.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AP009384; BAF90712.1; -; Genomic_DNA.
DR   AlphaFoldDB; A8I275; -.
DR   SMR; A8I275; -.
DR   STRING; 438753.AZC_4714; -.
DR   PRIDE; A8I275; -.
DR   EnsemblBacteria; BAF90712; BAF90712; AZC_4714.
DR   KEGG; azc:AZC_4714; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000270; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..931
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335115"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         674..681
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   931 AA;  100416 MW;  19091FDBF13D0E6C CRC64;
     MMDDTAMPAR AEADAAEDEL AAPAGIDRTA KADKDANRVS PMMAQYVEIK AANPGSLLFY
     RMGDFYELFF EDAEIASQAL GIVLTKRGKH LGEDIPMCGV PLTRSEEYLH KLIALGHRVA
     VCDQLEDPAE AKKRGSKSVV KRDVIRLVTP GTITEDSLLD AKRENVLLAV ARTRASGEGA
     YDYALAFTDV STGSFRVVAS DGDMLAADLA RIDPAEILVS DAVYDDEELR DFWRGLSTPV
     TPLPKQSFDG PQAEKRLAAF FGVATADSFG SFARAELIAA AAVVAYIERT QLGARPALAP
     PQREADGGSM LIDAGTRVNL ELIRTTSGER RGSLLAAIDR TVTAAGARLL ARRLAEPLTD
     IAAIRARHDA VGFLVEETEL REALRKRLAA APDLARALSR ISLGRGSPRD LGAIAAGLKE
     GLAISSAFGP ETPRDIARCA RLLAAVEPWL AEELTAALAD ELPLNRRDGG FVRQGYDLDL
     DSTRALRDES RRVVAALERR YVDETGIKSL KIRHNAVLGY FVEVTAQNAD RLREAPFNAT
     FVHRQTMAGA VRFTSVELGD LESRIASAGE RALALEQTIF DRLAAAVIEA SRPIREAAEA
     LAELDVLTAL ARLAVDERYV RPEMTEGVDF AISGGRHPVV EQALARGGGP FVANDCDLSP
     PETAQDARIW LVTGPNMAGK STFLRQNALI AVLAQAGAFV PARAARLGVV DRLFSRVGAA
     DDLARGRSTF MVEMVETAAI LNQATRRSLV ILDEIGRGTS TFDGMSIAWA SLEHLHEVNR
     CRALFATHFH ELTALTQRCQ RLANATVKVT EWQGDVVFLH EVIPGAADRS YGIQVAKLAG
     LPKMVIARAK AVLTELEAAE RVSPAQRLLD ELPLFAAAAR PAPTLAAPTG PHPAEPVLEE
     LDRLDPDALT PRAALDALYR LKAMLRDAAD D