ID   MUTS_AZOSB              Reviewed;         872 AA.
AC   A1K764;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=azo2052;
OS   Azoarcus sp. (strain BH72).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC   Azoarcus.
OX   NCBI_TaxID=418699;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BH72;
RX   PubMed=17057704; DOI=10.1038/nbt1243;
RA   Krause A., Ramakumar A., Bartels D., Battistoni F., Bekel T., Boch J.,
RA   Boehm M., Friedrich F., Hurek T., Krause L., Linke B., McHardy A.C.,
RA   Sarkar A., Schneiker S., Syed A.A., Thauer R., Vorhoelter F.-J.,
RA   Weidner S., Puehler A., Reinhold-Hurek B., Kaiser O., Goesmann A.;
RT   "Complete genome of the mutualistic, N2-fixing grass endophyte Azoarcus sp.
RT   strain BH72.";
RL   Nat. Biotechnol. 24:1385-1391(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAL94669.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AM406670; CAL94669.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; A1K764; -.
DR   SMR; A1K764; -.
DR   STRING; 62928.azo2052; -.
DR   EnsemblBacteria; CAL94669; CAL94669; azo2052.
DR   KEGG; azo:azo2052; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002588; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..872
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335114"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         632..639
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   872 AA;  95333 MW;  AE423FA1769429FC CRC64;
     MSISKIESVN AEKQSPVGTE IGTHTPMMQQ YLRIKEQHPD TLLFYRMGDF YELFFEDAEK
     AARLLDITLT TRGQSAGMPI RMAGVPFHAV EQYLARLVKL GESVVIAEQV GEPGATKGPM
     ERAVSRIVTP GTLTDAALLD DRRDALLLAA NMHRGVLGMA WLNLANGEFR LMECPAESLQ
     AQFERLRPAE VLIPDGLALP LMETLAPALR RLADWQFDAD TAHRLLTTHF GTRDLAGFGV
     EEAPVALGAA AALYDYAKAT QRQSLAHLTG LRLEREAEFL RLDAATRRNL ELTETLRGEP
     SPTLLSLLDT CMTSMGSRWL RHALHHPLRD RTIPAARQQA VAALVGDGDG LHAQAVRGAL
     RGVADVDRIT GRIALRNARP RDLSALRESL SRLPELRQTL AQIGDEGMVG GLAAALDVQP
     ELLQCLQRAI ADEPAAMVRD GGVIAAGYDA ELDELRGIQT NCGEFLMALE ARERERSGIA
     NLKVEFNKVH GFYIEVSHAN ADKVPDDYRR RQTLKNVERY ITPELKAFED KALSAQERAL
     AREKALYEAL LDALSPYIPA LQGCARALAT LDGLAAFAEA ALRYGYVRPV FSDQPGIEIR
     GGRHPVVERQ VEDFIQNDAR LGSTRRMLMI TGPNMGGKST FMRQVALICL LAHVGSFVPA
     QSAVLGPLDA IFTRIGASDD LASGRSTFMV EMTEASAILH GATEHSLVLM DEIGRGTSTF
     DGLALAFAIA RHLLEKNRSL TLFATHYFEL TRLNGEYPEC ANVHLDAVEH GHRIVFLHAL
     EDGPASQSYG IEVAALAGIP APVIRDAKRR LRALENREVG AGPQADLFAA LPDDDDAPLS
     HPVLIALAEI DPDSLSPREA LERLYALKRL SA