ID   MUTS_AZOVI              Reviewed;         855 AA.
AC   P27345;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutS;
GN   Name=mutS;
OS   Azotobacter vinelandii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Azotobacter.
OX   NCBI_TaxID=354;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 13705 / OP1 / DSM 366 / NCIMB 11614 / LMG 3878 / UW;
RX   PubMed=8244942; DOI=10.1128/jb.175.23.7707-7710.1993;
RA   Le O., Shen B., Iismaa S.E., Burgess B.K.;
RT   "Azotobacter vinelandii mutS: nucleotide sequence and mutant analysis.";
RL   J. Bacteriol. 175:7707-7710(1993).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; M63007; AAA16868.1; -; Unassigned_DNA.
DR   PIR; A53296; A53296.
DR   AlphaFoldDB; P27345; -.
DR   SMR; P27345; -.
DR   PRIDE; P27345; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..855
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115065"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   855 AA;  95078 MW;  12BB8269F9522005 CRC64;
     MESLSQHTPM MQQYWKLKRE HPDQLMFYRM GDFYELFYED AKKAAKLLDI TLTARGQSAG
     KSIPMAGIPF HSVEGYLAKL VKLGESVAIC EQIGDPATTK GPVERQVVRI ITPGTVSDEA
     LLDERRDNLL AAVVGDERLF GLAILDITSG RFNVQEIQGW ENLLAELERL NPAELLYPDD
     WPAGLPLEKR RGAHRRAPWD FDFDSAYKSL CQQFATQDLK GFGCDGLGLA IGAAGCLLAY
     ARETQRTALP HLRGLRHERL DDTVILAGAS RRNLELDVNL SGGRDNTLQS VIDRCQTAMG
     SRLLGRWLNR PLRDRAVLEA RQDTVACLLQ DYRFESLQPQ LKEIGDVERI LARIGLRNAR
     PRDLARLRDA LAALPQLQTA LSPLEAPHLQ ALAGNIRTYP ELAELLRRAI IDNPPAVIRD
     GGVLKQGYDA ELDELLSLSE NAGQFLMDLE AREKARTGLP NLKVGYNRIH GYYIELPRVQ
     AEQAPADYIR RQTLKGAERF ITPELKAFED KALSAKSRAL AREKALYEEL LEILIAQLAP
     LQETATALAE LDVLANLAER ALNLDFNRPR FVEEPCLRIR QGRHPVVEQV LDTPFVANDL
     ELDDNTRMLI ITGPNMGGKS TYMRQTALIV LLAHIGSFVP AQSCELSLVD RIFTRIGSSD
     DLAGGRSTFM VEMSETANIL HNASERSLVL MDEVGRGTST FDGLSLAWAA AEHLAGLRAW
     TLFATHYFEL TVLAESQPVV ANVHLSATEH NERIVFLHHV LPGPASQSYG LAVAQLAGVP
     GPVISRAREH LARLEATSLP HEAPLREAGK PQPPIQSDLF ASLPHPLMEE LARLKPDDLS
     PRQALELLYS WKTRL