MUTS_BACAH
ID MUTS_BACAH Reviewed; 890 AA.
AC A0RHE1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BALH_3397;
OS Bacillus thuringiensis (strain Al Hakam).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=412694;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Al Hakam;
RX PubMed=17337577; DOI=10.1128/jb.00241-07;
RA Challacombe J.F., Altherr M.R., Xie G., Bhotika S.S., Brown N., Bruce D.,
RA Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C.,
RA Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A.,
RA Green L.D., Han C.S., Hill K.K., Hitchcock P., Jackson P.J., Keim P.,
RA Kewalramani A.R., Longmire J., Lucas S., Malfatti S., Martinez D.,
RA McMurry K., Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C.,
RA Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P.,
RA Robinson D.L., Saunders E., Tapia R., Tesmer J.G., Thayer N.,
RA Thompson L.S., Tice H., Ticknor L.O., Wills P.L., Gilna P., Brettin T.S.;
RT "The complete genome sequence of Bacillus thuringiensis Al Hakam.";
RL J. Bacteriol. 189:3680-3681(2007).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000485; ABK86634.1; -; Genomic_DNA.
DR RefSeq; WP_000196010.1; NC_008600.1.
DR AlphaFoldDB; A0RHE1; -.
DR SMR; A0RHE1; -.
DR EnsemblBacteria; ABK86634; ABK86634; BALH_3397.
DR KEGG; btl:BALH_3397; -.
DR HOGENOM; CLU_002472_3_1_9; -.
DR OMA; TPMMAQY; -.
DR Proteomes; UP000000761; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..890
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000008045"
FT BINDING 607..614
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 890 AA; 100841 MW; FAA53FA35E5E27E1 CRC64;
MTQYTPMIQQ YLKVKADYQD AFLFFRLGDF YEMFFEDAVK AAHELEITLT SRDGGSSERI
PMCGVPYHAA KNYIEQLVEK GYKVAVCEQV EDPKTAKGVV RREVVQLITP GTMMEGRTID
EKENNFLAAL THFEDGSYAL ACNDLTTGQN TVTLLTGSVE DILLEVYATG SKEIVVDSSF
SKDELNKLTE TLKMTISYED ATAIPEGLEH LVKNVSQAKL IKAVGRLFNY VIRTQKRSLD
HLQPVEIYYT NQFMKIDVHS KRNLELTETL RTKEKTGSLL WLLDKTKTAM GGRMLKQWME
RPLIQKERIE ERLEMVETFV NDYFLREDLK EKLKEVYDLE RLAGKVAFGN VNARDLLQLR
RSLLQVPAIL EAISLLDNAY AARLIQGADP CESLTELLGR SIQENPPLSI KDGDIIKDGY
NDKLDQYRYV SKNGKTWIAE LEKRERDITG IKSLKIGYNR IFGYYIEVTK ANLGALPEGR
YERKQTLANA ERFITDELKE KETLILEAEE KIVQLEYDLF TALREEVKVF IPKLQHLAKV
ISELDVLQSF ATVSEEEQFV KPVLTTKREI FIKDGRHPVV EKVLNGKLYV PNDCIMPENM
DVFLITGPNM SGKSTYMRQL ALVTVMSQIG CFVPATEAVL PVFDQIFTRI GAADDLISGQ
STFMVEMLEA KNAIANASER SLILFDEIGR GTSTYDGMAL AQAIIEHIHD QIGAKTLFST
HYHELTVLED SLDQLKNVHV SAIEENGKVV FLHKIQDGAA DKSYGIHVAQ LAELPDSLIA
RAKEVLAQLE GQEEIVIPKR VEVKEQEVIP EPVVVKEEPV AIEETKVDNE EESQLSFFGA
EQSSKKQDKP VLDAKETAVL TQIKKIDLLD MTPLEAMNEL YRLQKKLKKG