ID   MUTS_BACC1              Reviewed;         892 AA.
AC   P61665;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BCE_3803;
OS   Bacillus cereus (strain ATCC 10987 / NRS 248).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=222523;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10987 / NRS 248;
RX   PubMed=14960714; DOI=10.1093/nar/gkh258;
RA   Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L.,
RA   Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F.,
RA   Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D.;
RT   "The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic
RT   adaptations and a large plasmid related to Bacillus anthracis pXO1.";
RL   Nucleic Acids Res. 32:977-988(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE017194; AAS42708.1; -; Genomic_DNA.
DR   RefSeq; WP_000196017.1; NC_003909.8.
DR   AlphaFoldDB; P61665; -.
DR   SMR; P61665; -.
DR   EnsemblBacteria; AAS42708; AAS42708; BCE_3803.
DR   GeneID; 59155735; -.
DR   KEGG; bca:BCE_3803; -.
DR   HOGENOM; CLU_002472_3_2_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002527; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..892
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115067"
FT   REGION          833..854
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         607..614
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   892 AA;  101138 MW;  292D0F6DF6BB80D8 CRC64;
     MTQYTPMIQQ YLKVKADYQD AFLFFRLGDF YEMFFEDAVK AAHELEITLT SRDGGSSERI
     PMCGVPYHAA KNYIEQLVEK GYKVAVCEQV EDPKTAKGVV RREVVQLITP GTMMEGRTID
     EKENNFLAAL THFEDGSYAL ACNDLTTGQN TVTLLTGSVE DILLEVYATG SKEIVVDSSF
     SKDELNKLTE TLKMTISYED ATAIPEGLEH LVKNVSQAKL IKAVGRLFNY VIRTQKRSLD
     HLQPVEIYYT NQFMKIDVHS KRNLELTETL RTKEKTGSLL WLLDKTKTAM GGRMLKQWME
     RPLIQKERIE ERLEMVETFV NDYFLREDLK EKLKEVYDLE RLAGKVAFGN VNARDLLQLR
     RSLLQVPAIL EAISLLDNAY AARLIQGADP CESLTELLGR SIQENPPLSI KDGDIIKDGY
     NDKLDQYRYV SKNGKTWIAE LEKRERDITG IKSLKIGYNR IFGYYIEVTK ANLGALPEGR
     YERKQTLANA ERFITDELKE KETLILEAEE KIVQLEYDLF TALREEVKVF IPKLQHLAKV
     ISELDVLQSF ATVSEEEQFV KPVLTTKREI FIKDGRHPVV EKVLNGKLYV PNDCIMPENM
     DVFLITGPNM SGKSTYMRQL ALVTVMSQIG CFVPATEAVL PVFDQIFTRI GAADDLISGQ
     STFMVEMLEA KNAIANASER SLILFDEIGR GTSTYDGMAL AQAIIEHIHD QIGAKTLFST
     HYHELTVLEE SLDQLKNVHV SAIEENGKVV FLHKIQDGAA DKSYGIHVAQ LAELPDSLIA
     RAKEVLAQLE GQEEIIIPKR VEVKMQEQEV IPEPVVVKEA PVEIEETKVE NEEESQLSFF
     GGEQSPKKQD KPVLDTKETA VLAQIKKIDL LDMTPLEAMN ELYRLQKKLK KG