ID   MUTS_BACC3              Reviewed;         890 AA.
AC   C1ENZ3;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BCA_3866;
OS   Bacillus cereus (strain 03BB102).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=572264;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=03BB102;
RA   Dodson R.J., Jackson P., Munk A.C., Brettin T., Bruce D., Detter C.,
RA   Tapia R., Han C., Sutton G., Sims D.;
RT   "Genome sequence of Bacillus cereus 03BB102.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001407; ACO28204.1; -; Genomic_DNA.
DR   RefSeq; WP_000196011.1; NZ_CP009318.1.
DR   AlphaFoldDB; C1ENZ3; -.
DR   SMR; C1ENZ3; -.
DR   EnsemblBacteria; ACO28204; ACO28204; BCA_3866.
DR   KEGG; bcx:BCA_3866; -.
DR   PATRIC; fig|572264.18.peg.3824; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002210; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..890
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000192196"
FT   REGION          832..851
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         607..614
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   890 AA;  100871 MW;  FAA525135E4497E1 CRC64;
     MTQYTPMIQQ YLKVKADYQD AFLFFRLGDF YEMFFEDAVK AAHELEITLT SRDGGSSERI
     PMCGVPYHAA KNYIEQLVEK GYKVAVCEQV EDPKTAKGVV RREVVQLITP GTMMEGRTID
     EKENNFLAAL THFEDGSYAL ACNDLTTGQN TVTLLTGSVE DILLEVYATG SKEIVVDSSF
     SKDELNKLTE TLKMTISYED ATAIPEGLEH LVKNVSQAKL IKAVGRLFNY VIRTQKRSLD
     HLQPVEIYYT NQFMKIDVHS KRNLELTETL RTKEKTGSLL WLLDKTKTAM GGRMLKQWME
     RPLIQKERIE ERLEMVETFV NDYFLREDLK EKLKEVYDLE RLAGKVAFGN VNARDLLQLR
     RSLLQVPAIL EAISLLDNAY AARLIQGADP CESLTELLGR SIQENPPLSI KDGDIIKDGY
     NDKLDQYRYV SKNGKTWIAE LEKRERDITG IKSLKIGYNR IFGYYIEVTK ANLGALPEGR
     YERKQTLANA ERFITDELKE KETLILEAEE KIVQLEYDLF TALREEVKVF IPKLQHLAKV
     ISELDVLQSF ATVSEEEQFV KPVLTTKREI FIKDGRHPVV EKVLNGKLYV PNDCIMPENM
     DVFLITGPNM SGKSTYMRQL ALVTVMSQIG CFVPATEAVL PVFDQIFTRI GAADDLISGQ
     STFMVEMLEA KNAIANASER SLILFDEIGR GTSTYDGMAL AQAIIEHIHD QIGAKTLFST
     HYHELTVLED SLDQLKNVHV SAIEENGKVV FLHKIQDGAA DKSYGIHVAQ LAELPDSLIA
     RAKEVLAQLE GQEEIVIPKR VEVKEQEVIP EPVVVKEEPV AIEETKVDNE EESQLSFFGT
     EQSSKKQDKP VLDAKETAVL TQIKKIDLLD MTPLEAMNEL YRLQKKLKKG