ID   MUTS_BACCR              Reviewed;         884 AA.
AC   Q81A25;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BC_3769;
OS   Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC
OS   15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=226900;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373
RC   / NCTC 2599 / NRRL B-3711;
RX   PubMed=12721630; DOI=10.1038/nature01582;
RA   Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V.,
RA   Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M.,
RA   Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G.,
RA   Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.;
RT   "Genome sequence of Bacillus cereus and comparative analysis with Bacillus
RT   anthracis.";
RL   Nature 423:87-91(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE016877; AAP10693.1; -; Genomic_DNA.
DR   RefSeq; NP_833492.1; NC_004722.1.
DR   AlphaFoldDB; Q81A25; -.
DR   SMR; Q81A25; -.
DR   STRING; 226900.BC_3769; -.
DR   EnsemblBacteria; AAP10693; AAP10693; BC_3769.
DR   KEGG; bce:BC3769; -.
DR   PATRIC; fig|226900.8.peg.3885; -.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001417; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..884
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115068"
FT   REGION          826..845
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         601..608
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   884 AA;  100180 MW;  3EDF3E9B58D9108D CRC64;
     MIQQYLKVKA DYQDAFLFFR LGDFYEMFFE DAVKAAHELE ITLTSRDGGS SERIPMCGVP
     YHAAKNYIEQ LVEKGYKVAV CEQVEDPKTA KGVVRREVVQ LITPGTMMEG RTIDEKENNF
     LAALTHFEDG SYALACNDLT TGQNTVTLLT GSVEDILLEV YATGSKEIVV DSSFSKDELN
     KLTETLKMTI SYEDATAIPE GLEHLVKNVS QAKLIKAVGR LFNYVIRTQK RSLDHLQPVE
     IYYTNQFMKI DVHSKRNLEL TETLRTKEKT GSLLWLLDKT KTAMGGRMLK QWMERPLIQK
     ERIEERLEMV ETFVNDYFLR EDLKEKLKEV YDLERLAGKV AFGNVNARDL LQLRRSLLQV
     PAILEAISLL DNAYASRLIQ GADPCESLTE LLGRSIQENP PLSIKDGDII KDGYNDKLDQ
     YRYVSKNGKT WIAELEKRER DITGIKSLKI GYNRIFGYYI EVTKANLAAL PEGRYERKQT
     LANAERFITD ELKEKETLIL EAEEKIVQLE YDLFTALREE VKVFIPKLQH LAKVISELDV
     LQSFATVSEE EQFVKLVLTT KREIFIKDGR HPVVEKVLNG KLYVPNDCIM PEKMDVFLIT
     GPNMSGKSTY MRQLALVTVM SQIGCFVPAT EAVLPVFDQI FTRIGAADDL ISGQSTFMVE
     MLEAKNAIAN ASERSLILFD EIGRGTSTYD GMALAQAIIE HIHDQIGAKT LFSTHYHELT
     VLEESLDQLK NVHVSAIEEN GKVVFLHKIQ DGAADKSYGI HVAQLAELPD SLIARAKEVL
     AQLEGQEEII IPKRVEVKVQ EAAPEPVVVK EEIAEIQETK VETEEESQLS FFGGEQSSKK
     QDKPLLDQKE TAVLAQIKKI DLLDMTPLEA MNELYRLQKK LKKG