ID   MUTS_BACFN              Reviewed;         879 AA.
AC   Q5L7B7;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BF4369;
OS   Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019
OS   / NCTC 9343 / Onslow).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=272559;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow;
RX   PubMed=15746427; DOI=10.1126/science.1107008;
RA   Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V.,
RA   Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A.,
RA   Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A.,
RA   Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J.,
RA   Barrell B.G., Parkhill J.;
RT   "Extensive DNA inversions in the B. fragilis genome control variable gene
RT   expression.";
RL   Science 307:1463-1465(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CR626927; CAH10035.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5L7B7; -.
DR   SMR; Q5L7B7; -.
DR   STRING; 272559.BF9343_4254; -.
DR   EnsemblBacteria; CAH10035; CAH10035; BF9343_4254.
DR   KEGG; bfs:BF9343_4254; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_10; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000006731; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..879
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224350"
FT   BINDING         625..632
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   879 AA;  99288 MW;  F51164CBA7BB7E84 CRC64;
     MNLKRRLSVS NDIELTPMMK QFLDLKAKHP DAVMLFRCGD FYETYSTDAI IAAEILGITL
     TKRANGKGKT VEMAGFPHHA LDTYLPKLIR AGKRVAICDQ LEDPKTTKKL VKRGITELVT
     PGVSINDNVL NYKENNFLAA VHFGKSACGI AFLDISTGEF LTAEGPFDYV DKLLNNFAPK
     EILFERGKRG MFEGNFGSKF FTFELDDWVF TESSSREKLL KHFETKNLKG FGVEHLKNGI
     IASGAILQYL DMTEHTQVGH ITSLARIEED KYVRLDKFTV RSLELIGSMN DGGSSLLHVI
     DKTISPMGAR LLKRWMVFPL KDEKPINDRL NVVEYFFRKP DFRELIEDEL HRIGDLERII
     SKVAVGRVSP REVVQLKVAL QAIEPIKEAC QQADNPSLNR IGEQLNLCIS IRDRIEKEIN
     NDPPLLINKG GVIKDGVDTE LDELRQIAYS GKDYLLKIQQ RESELTGIPS LKIAYNSVFG
     YYIEVRNVHK DKVPQEWIRK QTLVNAERYI TQELKEYEEK ILGAEDKILV LETRLYTELV
     QALSEFIPAI QINANQIARI DCLLSFANVA KENNYIRPVI EDNDVLDIRQ GRHPVIEKQL
     PIGEKYIAND VLLDNATQQV IIITGPNMAG KSALLRQTAL ITLLAQIGSF VPAESAHIGL
     VDKIFTRVGA SDNISVGEST FMVEMNEASD ILNNISSRSL VLFDELGRGT STYDGISIAW
     AIVEYIHEHP KAKARTLFAT HYHELNEMEK SFKRIKNYNV SVKEVDNKVI FLRKLERGGS
     EHSFGIHVAK MAGMPKSIVK RANEILKQLE SDNRQQGISG KPLAEVSENR GGMQLSFFQL
     DDPILCQIRD EILHLDVNNL TPIEALNKLN DIKKIVRGK