ID   MUTS_BACFR              Reviewed;         862 AA.
AC   Q64MG7;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BF4583;
OS   Bacteroides fragilis (strain YCH46).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=295405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YCH46;
RX   PubMed=15466707; DOI=10.1073/pnas.0404172101;
RA   Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N.,
RA   Kuhara S., Hattori M., Hayashi T., Ohnishi Y.;
RT   "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions
RT   regulating cell surface adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AP006841; BAD51320.1; -; Genomic_DNA.
DR   RefSeq; WP_011203750.1; NZ_UYXF01000012.1.
DR   RefSeq; YP_101854.1; NC_006347.1.
DR   AlphaFoldDB; Q64MG7; -.
DR   SMR; Q64MG7; -.
DR   STRING; 295405.BF4583; -.
DR   EnsemblBacteria; BAD51320; BAD51320; BF4583.
DR   KEGG; bfr:BF4583; -.
DR   PATRIC; fig|295405.11.peg.4408; -.
DR   HOGENOM; CLU_002472_3_1_10; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002197; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..862
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224349"
FT   BINDING         608..615
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   862 AA;  97320 MW;  ABCE83F6426F1FCE CRC64;
     MMKQFLDLKA KHPDAVMLFR CGDFYETYST DAIIAAEILG ITLTKRANGK GKTVEMAGFP
     HHALDTYLPK LIRAGKRVAI CDQLEDPKTT KKLVKRGITE LVTPGVSIND NVLNYKENNF
     LAAVHFGKSA CGIAFLDIST GEFLTAEGPF DYVDKLLNNF APKEILFERG KRGMFEGNFG
     SKFFTFELDD WVFTESSSRE KLLKHFETKN LKGFGVEHLK NGIIASGAIL QYLDMTEHTQ
     VGHITSLARI EEDKYVRLDK FTVRSLELIG SMNDGGSSLL HVIDKTISPM GARLLKRWMV
     FPLKDEKPIN DRLNVVEYFF RKPDFRELIE DELHRIGDLE RIISKVAVGR VSPREVVQLK
     VALQAIEPIK EACQQADNPS LNRIGEQLNL CISIRDRIEK EINNDPPLLI NKGGVIKDGV
     DTELDELRQI AYSGKDYLLK IQQRESELTG IPSLKIAYNS VFGYYIEVRN VHKDKVPQEW
     IRKQTLVNAE RYITQELKEY EEKILGAEDK ILVLETRLYT ELVQALSEFI PAIQINANQI
     ARIDCLLSFA NVAKENNYIR PVIEDNDVLD IRQGRHPVIE KQLPIGEKYI ANDVLLDNAT
     QQVIIITGPN MAGKSALLRQ TALITLLAQI GSFVPAESAH IGLVDKIFTR VGASDNISVG
     ESTFMVEMNE ASDILNNISS RSLVLFDELG RGTSTYDGIS IAWAIVEYIH EHPKAKARTL
     FATHYHELNE MEKSFKRIKN YNVSVKEVDN KVIFLRKLER GGSEHSFGIH VAKMAGMPKS
     IVKRANEILK QLESDNRQQG ISGKPLAEVS ENRGGMQLSF FQLDDPILCQ IRDEILHLDV
     NNLTPIEALN KLNDIKKIVR GK