MUTS_BACLD
ID MUTS_BACLD Reviewed; 869 AA.
AC Q65JE2; Q62UU6;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN OrderedLocusNames=BLi01928, BL03663;
OS Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 /
OS NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=279010;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX PubMed=15383718; DOI=10.1159/000079829;
RA Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P.,
RA Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.;
RT "The complete genome sequence of Bacillus licheniformis DSM13, an organism
RT with great industrial potential.";
RL J. Mol. Microbiol. Biotechnol. 7:204-211(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX PubMed=15461803; DOI=10.1186/gb-2004-5-10-r77;
RA Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J.,
RA Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B.,
RA Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A.,
RA Bolotin A., Lapidus A., Galleron N., Ehrlich S.D., Berka R.M.;
RT "Complete genome sequence of the industrial bacterium Bacillus
RT licheniformis and comparisons with closely related Bacillus species.";
RL Genome Biol. 5:R77.1-R77.12(2004).
RN [3]
RP SEQUENCE REVISION TO 534.
RA Berka R.M., Rey M.W., Ramaiya P.;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; AE017333; AAU40822.1; -; Genomic_DNA.
DR EMBL; CP000002; AAU23463.2; -; Genomic_DNA.
DR RefSeq; WP_011197985.1; NC_006322.1.
DR AlphaFoldDB; Q65JE2; -.
DR SMR; Q65JE2; -.
DR STRING; 279010.BL03663; -.
DR EnsemblBacteria; AAU23463; AAU23463; BL03663.
DR GeneID; 66216062; -.
DR KEGG; bld:BLi01928; -.
DR KEGG; bli:BL03663; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_9; -.
DR OMA; TPMMAQY; -.
DR OrthoDB; 15991at2; -.
DR BioCyc; BLIC279010:BLI_RS09535-MON; -.
DR Proteomes; UP000000606; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..869
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000224347"
FT BINDING 602..609
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 869 AA; 98515 MW; 6D4DA2ECED9F7A4A CRC64;
MAGYTPMIQQ YLKIKAEYQD AFLFFRLGDF YEMFFEDAKK ASQELEITLT SRDGGSSERI
PMCGVPYHSC SSYIEQLIKK GYKVAICEQV EDPKSAKGVV KREVVQLITP GTVMDGKGIH
ENENNFIASV SKFQHTYGLA FSDLTTGENL VTAIERLDDV VSEIYSVGAR EIVVSRNLDE
KDVAMLKERC GATISFEDEQ ADEVPGIVNG LGSKELVDTF MRLYVYLKRT QKRSLDHLQN
VQAYELEEAM KIDLYSKRNL ELTETIRSKN KKGSLLWLLD ETKTAMGGRL LKQWIDRPLI
RKGQIEERQE IVETLIAHLF EREDLRERLK EVYDLERLAG RVAYGNVNAR DLIQLKESLK
QVPAIKQLVG SLDHPKAKAR AEKIDPCGDL LNLLEDALYE NPPLSLKEGN LIKDGYHAKL
DEYRDASKNG KDWIARLEQQ EREYTGIRSL KVGFNKVFGY YIEVTKANIH LLEEGRYERK
QTLTNAERYI TPELKEKEAL ILEAENNICE LEYELFSELR SKVKEYIPRL QQLAKMMSEL
DVLQCFATIS ENRHYVKPEF SDDVVQVIDG RHPVVEKVMD SQSYVPNSCE MGKGRQMLLI
TGPNMSGKST YMRQMALISI LAQIGCFVPA KKAVLPIFDQ IFTRIGAADD LISGQSTFMV
EMLEAKNAIV HATKNSLILF DEIGRGTSTY DGMALAQAII EYVHEHIGAK TLFSTHYHEL
TSLEEKLDDL KNVHVRAEEY EGKVVFLHQI KEGAADKSYG IHVAQLAELP DGLISRAKTI
LKELESGAKE AAPSTAPNMV KEAAEEAAAT VADQPAQLSF FETDKPIEKE TKLSKKEQAV
LAEFKAMDLL DMTPIQVMNE LYRLQKKLK
