ID   MUTS_BACP2              Reviewed;         858 AA.
AC   A8FDH3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BPUM_1608;
OS   Bacillus pumilus (strain SAFR-032).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=315750;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SAFR-032;
RX   PubMed=17895969; DOI=10.1371/journal.pone.0000928;
RA   Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D.,
RA   Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H.,
RA   Lee S., Nazareth L., Blyth P., Holder M., Buhay C., Tirumalai M.R., Liu Y.,
RA   Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P.,
RA   Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D.,
RA   Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F.,
RA   Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K.,
RA   Weinstock G.M.;
RT   "Paradoxical DNA repair and peroxide resistance gene conservation in
RT   Bacillus pumilus SAFR-032.";
RL   PLoS ONE 2:E928-E928(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000813; ABV62290.1; -; Genomic_DNA.
DR   RefSeq; WP_012010027.1; NZ_VEIC01000002.1.
DR   AlphaFoldDB; A8FDH3; -.
DR   SMR; A8FDH3; -.
DR   STRING; 315750.BPUM_1608; -.
DR   EnsemblBacteria; ABV62290; ABV62290; BPUM_1608.
DR   KEGG; bpu:BPUM_1608; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001355; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..858
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000057633"
FT   BINDING         600..607
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   858 AA;  97901 MW;  255280C920AEF02B CRC64;
     MASYTPMIQQ YLNIKAEYQD AFLFFRLGDF YEMFFDDAKE ASQELEITLT SRDGGTIPMC
     GVPYHSASAY IEQLISKGYK VAICEQVEDP KTAKGVVKRE VVQLITPGTV MEGKGLSENE
     NNFIASVTKF ENGYGLALSD LSTGENMAAF IDRLDEVVSE IYSVGAKEIV VSKHLDEETV
     KTLKERCQAT ISYEDSDELI DEAERLVSRL SEQLRSTFLT LYAYLRRTQK RSLDHLQQVQ
     VFELEQTMKI DLYSKRNLEL TETIRSKSKK GSLLWLLDET KTAMGGRLLK QWIDRPLIRL
     SHIKERQEMV QILMDHFFER EDLRERLKQV YDLERLAGRV AFGNVNARDL IQLKESLKQV
     PAIKELVHSL PEEMAKSRAN DIDLCDDLLN LLEDALYENP PMTLKEGNLI KDGYNAKLDE
     YRDASRNGKD WIARLEQQER EYTGIRSLKV GFNKVFGYYI EVTRANTHLL EEGRYERKQT
     LANAERYITP ELKEKEALIL EAESNISELE YELFAALREQ VKVYIPRLQL LAKQMSELDA
     LQCFATVSEK RRYIRPEFSE DEVDVIDGRH PVVEKVMDHQ EYVPNDCHMG NGRQTLLITG
     PNMSGKSTYM RQMALISILA QIGCFVPASK ATLPIFDQIF TRIGAADDLI SGQSTFMVEM
     LEAKNAMVHA TKNSLILFDE IGRGTSTYDG MALAQAIIEF VHDHVGAKTL FSTHYHELTV
     LESQLSELKN VHVRAEEHEG TVVFLHQIKE GAADKSYGIH VAQLAELPDA IIDRAQTILT
     ELESGSHEVT PHVSAAPKTE KAEEKQQLSF FEVEEKPQTK PVLKQKDQAV IEELKSFNLM
     DMTPLEAMTK LYELQKKL