ID   MUTS_BACTN              Reviewed;         862 AA.
AC   Q8A334;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BT_3121;
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS   CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50;
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA   Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE015928; AAO78227.1; -; Genomic_DNA.
DR   RefSeq; NP_812033.1; NC_004663.1.
DR   RefSeq; WP_011108646.1; NZ_UYXG01000001.1.
DR   AlphaFoldDB; Q8A334; -.
DR   SMR; Q8A334; -.
DR   STRING; 226186.BT_3121; -.
DR   PaxDb; Q8A334; -.
DR   PRIDE; Q8A334; -.
DR   EnsemblBacteria; AAO78227; AAO78227; BT_3121.
DR   GeneID; 60924303; -.
DR   KEGG; bth:BT_3121; -.
DR   PATRIC; fig|226186.12.peg.3185; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_10; -.
DR   InParanoid; Q8A334; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001414; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..862
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115071"
FT   BINDING         608..615
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   862 AA;  97331 MW;  359ED62FB8139C59 CRC64;
     MMKQFLDLKA KHPDAVMLFR CGDFYETYST DAIVASEILG ITLTKRANGK GKTIEMAGFP
     HHALDTYLPK LIRAGKRVAI CDQLEDPKLT KKLVKRGITE LVTPGVSIND NVLNYKENNF
     LAAVHFGKAS CGVAFLDIST GEFLTAEGPF DYVDKLLNNF GPKEILFERG KRLMFEGNFG
     SKFFTFELDD WVFTESTARE KLLKHFETKN LKGFGVEHLK NGIIASGAIL QYLTMTQHTQ
     IGHITSLARI EEDKYVRLDK FTVRSLELIG SMNDGGSSLL NVIDRTISPM GARLLKRWMV
     FPLKDEKPIN DRLNVVEYFF RQPDFKELIE EQLHLIGDLE RIISKVAVGR VSPREVVQLK
     VALQAIEPIK QACLEADNAS LNRIGEQLNL CISIRDRIAK EINNDPPLLI NKGGVIKDGV
     NEELDELRRI SYSGKDYLLQ IQQRESEQTG IPSLKVAYNN VFGYYIEVRN IHKDKVPQEW
     IRKQTLVNAE RYITQELKVY EEKILGAEDK ILVLETQLYT DLVQALTEFI PQIQINANQI
     ARLDCLLSFA NVARENNYIR PVIEDNDVLD IRQGRHPVIE KQLPIGEKYI ANDVMLDSAS
     QQIIIITGPN MAGKSALLRQ TALITLLAQI GSFVPAESAH IGLVDKIFTR VGASDNISVG
     ESTFMVEMNE AADILNNVSS RSLVLFDELG RGTSTYDGIS IAWAIVEYIH EHPKAKARTL
     FATHYHELNE MEKSFKRIKN YNVSVKEVDN KVIFLRKLER GGSEHSFGIH VAKMAGMPKS
     IVKRANTILK QLESDNRQQG ISGKPLTEVS ENRSGMQLSF FQLDDPILCQ IRDEILNLDV
     NNLTPIEALN KLNDIKKIVR GK