ID   MUTS_BACVZ              Reviewed;         862 AA.
AC   A7Z4X5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RBAM_016880;
OS   Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42)
OS   (Bacillus amyloliquefaciens subsp. plantarum).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus amyloliquefaciens group.
OX   NCBI_TaxID=326423;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42;
RX   PubMed=17704766; DOI=10.1038/nbt1325;
RA   Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K.,
RA   Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H.,
RA   Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H.,
RA   Strittmatter A., Gottschalk G., Borriss R.;
RT   "Comparative analysis of the complete genome sequence of the plant growth-
RT   promoting bacterium Bacillus amyloliquefaciens FZB42.";
RL   Nat. Biotechnol. 25:1007-1014(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000560; ABS74051.1; -; Genomic_DNA.
DR   AlphaFoldDB; A7Z4X5; -.
DR   SMR; A7Z4X5; -.
DR   STRING; 326423.RBAM_016880; -.
DR   EnsemblBacteria; ABS74051; ABS74051; RBAM_016880.
DR   KEGG; bay:RBAM_016880; -.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001120; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..862
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335116"
FT   BINDING         603..610
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   862 AA;  97941 MW;  2D5FEB6059711D5F CRC64;
     MMASYTPMIQ QYLKIKAEHQ DAFLFFRLGD FYEMFFEDAK KASQELEITL TSRDGGSADK
     IPMCGVPYHS AAAYIEQLIK KGYKVAICEQ TEDPKAAKGV VKREVVQLIT PGTVMDGKGI
     HESENNFIAS VSEFRDGYGL ALSDLTTGEN LAVFIERIED VMSEIYSVSA KEIVVSSKFN
     EHTAAQLKER CGATISIEDG EITERIEIAK HLPGEELTET FMRLYTYLQK TQKRSLDHLQ
     PVQVYELEEA MKIDLYSKRN LELTETIRSK SKKGSLLWLL DETKTAMGGR LLKQWIDRPL
     IRASQIEERQ EMVETLINHL FEREDLRERL KEVYDLERLA GRVAFGNVNA RDLIQLKESL
     KQVPSIKELV GSLNHKKAKE RAGLIDPCGD LLDLLEEALH ENPPLSLKEG NLIKDGYHQK
     LDEYRDASKN GKDWIARLEQ QERAYTGIRS LKVGFNKVFG YYIEVTKANL HLLEDGRYER
     KQTLTNAERY ITPELKEKEA LILEAENNIC ELEYELFAVL REKVKQFIPR LQRLAKQMSE
     LDALQCFATI SENRHYTKPV FSDNEVKVIE GRHPVVEKVM DSQEYVPNNC LMGDSREMLL
     ITGPNMSGKS TYMRQIALLS IMAQIGCFVP AKEAVLPIFD QIFTRIGAAD DLISGQSTFM
     VEMLEAKNAI VNATKDSLIL FDEIGRGTST YDGMALAQAI IEYVHDHIGA KTLFSTHYHE
     LTVLEDKLPQ LKNVHVRAEE YNGTVVFLHQ IKEGAADKSY GIHVAQLAEL PDDLISRAQE
     ILKQLEQTGD KPELPAVSEK KSAVREEPAQ LSFFADGEKE QKAPAVSNKE KQVLEAFKSI
     NILDMTPLEA MNEMYKLQKK LK