ID   MUTS_BARBK              Reviewed;         914 AA.
AC   A1UU95;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=BARBAKC583_1299;
OS   Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=360095;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35685 / NCTC 12138 / KC583;
RA   Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S.,
RA   Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R.,
RA   Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J.,
RA   Fraser-Ligget C., Seshadri R.;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000524; ABM44881.1; -; Genomic_DNA.
DR   RefSeq; WP_005768075.1; NC_008783.1.
DR   AlphaFoldDB; A1UU95; -.
DR   SMR; A1UU95; -.
DR   STRING; 360095.BARBAKC583_1299; -.
DR   EnsemblBacteria; ABM44881; ABM44881; BARBAKC583_1299.
DR   KEGG; bbk:BARBAKC583_1299; -.
DR   PATRIC; fig|360095.6.peg.1273; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000643; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..914
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008046"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         662..669
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   914 AA;  102388 MW;  F36680AB8EF531C1 CRC64;
     MEKGTEHKSN VTLQSFTSSS THQERLTPMM EQYIEIKAVN NDCLLFYRMG DFYELFFNDA
     IIASQALGIT LTTRGKHLGK DIPMCGVPVH SADDYLQKLI ACGYRVAVCE QMEDPAEAKK
     RGSKSIVQRE VVRLVTPGTI TEEKLLDPTR ANYLMTLARI KTSDREEFAL SWIDISTGIF
     RVTESHHEKL LTDIMRVDPQ EVIVADSLLH DKSLKSLFNV LGHIISPQSA TLFDTITAEH
     DICNYFKLST LEGVADYSRP ELSAIAAAIR YIEKTQITHR PPLMRPERQN EKATLFIDAA
     TRLNLELIRT TSGQRDGSLL KTIDRTVTGG GSRLLADRLI SPLTSPEAID KRLDSIAFFL
     RNTSLSEAAH LILKGGPDMS RAVSRLALGR GEPRDIATIR RGFEIISELN QLLNNKLLPQ
     EISDVKEVFS RLPTALHIRL NQALTDDLPL LKRDGGFIRP NYHQELDKMR NLRDESRRII
     AELQVRYAKE TDIKTLKIKH NNVLGYFIEV TTLQASALTN NPQAKAHFIH RQTIANAMRF
     TTTELAELES RIAHAANHVI TLELEIFDML VNEIIAQADF IRKVSEALAV LDVSVALAYL
     AEEQGYCRPI IDNSLTFHIT AGRHPVVEQA LRKQAIEPFV ANDCNLSAKN NHQYAAIWLL
     TGPNMGGKST FLRQNALIAI MAQMGSFVPA TSAHIGVVDR LFSRVGASDD LARGRSTFMM
     EMVETATILN HASSHSLVIL DEIGRGTSTF DGLSIAWAAV EYLHEVNHCR AILATHFHEM
     TALTKKLDRL HNVTMKVKNW EGNVIFLHEV TEGAADRSYG VQVAKLAGLP EEVITRATDV
     LHQLEQSEMA GKGHKLIDDL PLFNLQTIST THKKTDKYDA IKEALKNIHP DELSPKDALE
     ELYRLKKLEK ESSL