ID   MUTS_BARHE              Reviewed;         914 AA.
AC   Q6G542;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BH01000;
OS   Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)
OS   (Rochalimaea henselae).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=283166;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49882 / DSM 28221 / Houston 1;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT   of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; BX897699; CAF26915.1; -; Genomic_DNA.
DR   RefSeq; WP_011180059.1; NZ_LRIJ02000001.1.
DR   AlphaFoldDB; Q6G542; -.
DR   SMR; Q6G542; -.
DR   STRING; 283166.BH01000; -.
DR   PaxDb; Q6G542; -.
DR   PRIDE; Q6G542; -.
DR   EnsemblBacteria; CAF26915; CAF26915; BH01000.
DR   KEGG; bhe:BH01000; -.
DR   eggNOG; COG0249; Bacteria.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000421; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..914
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224351"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         662..669
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   914 AA;  102163 MW;  EC53338E2F6A7D94 CRC64;
     MDNKTDNKNN LTPQSAPSSA PHKERLTPMM EQYIEIKAVN SDCLLFYRMG DFYELFFNDA
     IEAAQVLGIT LTTRGKHLGE DIPMCGVPVH TADDYLQKLI SCGYRVAVCE QTEDPAEAKK
     RGSKSIVRRD VVRLVTPGTL TEEKLLDPTR ANYLMTLARI KTSDGEEFAL SWIDISTGIF
     RVTESRLEKL LADIMRVDPQ EIIVADSFFH DKSHKSLFNV LDCIVSPQHA SLFDVITAER
     DICSYFKLST LEGIADYSRP ELSAIAAAIR YIEKTQITHR PPLMRPERQN ESATLFIDAA
     TRLSLELVRT TSGQRDGSLL KAIDRTVTGG GSRLLLDRLI APLTTPSAID KRLDSIAFFL
     RNTSLAEDIK LILKGGPDMP RAVSRLALGR GGPRDMASIQ RGFEIIRELH QLLSNELLPQ
     EISDVQQIFS HLPTALHLRL EQALADDLPL LKRDGGFIRP HYHKELDEMR TLRDESRRVI
     AELQAQYAQE TDIKTLKIKH NNILGYFIEV TNLQATALTN TPQAKARFIH RQTMANAMRF
     TTTELAELES RIAHAANHAL TLELEIFDTL VHEITEQVDF IRKAAESLAV LDVSVALAHL
     AEEQGYCRPK IDQSLTFCIT AGRHPVVEQA LRKQAAEPFV ANNCDLSLQE NHQYAAIWLL
     TGPNMGGKST FLRQNALIAI MAQMGSFVPA TSAHIGVVDR LFSRVGASDD LARGRSTFMM
     EMVETATILN HATQHSLVIL DEIGRGTSTF DGLSIAWATV EYLHEVNHCR AILATHFHEM
     TALTEKLDRL HNVTMKVKNW DGDVIFLHEV TPGAADRSYG VQVAKLAGLP KAVITRATDV
     LQQLEQGEMA GKGHKLIDDL PLFSLKTTSS LNEDTNKYSM LHEAFKNIHP DELSPKQALE
     ALYHLKQLEK NNPL