ID   MUTS_BARQU              Reviewed;         911 AA.
AC   Q6G0X1;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BQ00930;
OS   Bartonella quintana (strain Toulouse) (Rochalimaea quintana).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=283165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Toulouse;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT   of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; BX897700; CAF25599.1; -; Genomic_DNA.
DR   RefSeq; WP_011178924.1; NC_005955.1.
DR   AlphaFoldDB; Q6G0X1; -.
DR   SMR; Q6G0X1; -.
DR   STRING; 283165.BQ00930; -.
DR   PRIDE; Q6G0X1; -.
DR   EnsemblBacteria; CAF25599; CAF25599; BQ00930.
DR   KEGG; bqu:BQ00930; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000597; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..911
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224352"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         662..669
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   911 AA;  101798 MW;  F6FAC1B267E4B363 CRC64;
     MDNKTDHKND LNSQPVPSSA PHKERLTPMM EQYIEIKAVN SDSLLFYRMG DFYELFFNDA
     IEAAQVLGIT LTTRGKHLGE DIPMCGVPVH AADDYLQKLI SSGYRVAVCE QTEDPAEAKK
     RGSKSIVRRD VVRLVTPGTI TEEKLLDPTR ANYLMTLARI KTSKGEEFAL SWIDISTGIF
     RVTESHPEKL LADIMRVDPQ EIIVADSFFH DKSHKSLFNV LDRIVSPQHV SLFDAVTAER
     DICSYFKLST LEGVADYSRS ELSAIAAAIR YIEKTQITHR PPLMRPERQN ENATLFIDAA
     TRLSLELIRT TSGQRDGSLL KAIDRTVTGG GSRLLVDRLI APLTTPSAID KRLDSIAFFL
     RNTSLAEAIQ LILKGGPDMP RAVSRLALGR GGPRDIASIQ RGFEIIHGLN QLLNNELLPQ
     EISDVQQVFS HLPTALHFRL EQALSDDLPL LKRDGGFIRP NYHKELDEMR ALRDESRLII
     AELQAQYAKE TDIKTLKIKH NNILGYFIEI TNLQATALTN TPQAKARFIH RQTLANVMRF
     TTTELVELEG RIAHAATHAM TLELEIFDTL VHEITEQVDF IRKAAEALAI LDVSVALARL
     AEEQEYCRPK IDQSLTFRIT AGRHPVVEQA LRKQAAEPFV ANNCDLSVQK NHQYAAIWLL
     TGPNMGGKST FLRQNALITI MAQMGSFVPA SSAHIGVVDR LFSRVGASDD LARGRSTFMM
     EMVETATILN HASSHSLVIL DEIGRGTSTF DGLSIAWAAV EYLHEVNQCR AILATHFHEM
     TALTEKLDRL YNVTMKVKNW DGDVVFLHEV MPGAADRSYG VQVAKLAGLP TAVITRATDV
     LHQLEQGETA GKGNKLIDDL PLFSLKTTSL INEETNKHCM LHEALKNIYP DELSPKEALE
     VLYRLKQLEK K