ID   MUTS_BART1              Reviewed;         914 AA.
AC   A9ILT1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BT_0108;
OS   Bartonella tribocorum (strain CIP 105476 / IBS 506).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=382640;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CIP 105476 / IBS 506;
RX   PubMed=18037886; DOI=10.1038/ng.2007.38;
RA   Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G.,
RA   Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.;
RT   "Genomic analysis of Bartonella identifies type IV secretion systems as
RT   host adaptability factors.";
RL   Nat. Genet. 39:1469-1476(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM260525; CAK00598.1; -; Genomic_DNA.
DR   RefSeq; WP_012230428.1; NC_010161.1.
DR   AlphaFoldDB; A9ILT1; -.
DR   SMR; A9ILT1; -.
DR   STRING; 382640.BT_0108; -.
DR   EnsemblBacteria; CAK00598; CAK00598; BT_0108.
DR   KEGG; btr:BT_0108; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001592; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..914
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335118"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         662..669
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   914 AA;  101867 MW;  64C3A2925DD2E33E CRC64;
     MDKKNDHKNN LIPQPASSFA SSQERPTPMM EQYIEIKAVH HDSLLFYRMG DFYELFFNDA
     IEAAQALGIT LTARGKHLGQ DIPMCGVPVH AADDYLQKLI ACGYRVAVCE QTEDPAEAKK
     RGSKSVVRRD VVRLVTPGTI TEEKLLDPTR ANYLMTLSRI KTSDGEDFAL SWIDISTGIF
     RVTESRQEKL LADIMRVDPQ EIIVADAFFH DKSHKSLFNV LDHIVSPQPA CLFDTLTAER
     DICTYFKLST LEGVADYSRC ELSAIVAAIR YIEKTQITHR PPLMQPERQN ESATLFIDAA
     TRLSLELIRT TSGQRDGSLL KAIDRTVTGG GSRLLIDRLI APLTTPSAID TRLDSIDFFL
     RNPSLAEAIK LVLKGGPDMP RAVSRLALGR GGPRDMATIQ RGFEIIRELN QILNNELLPQ
     EISDVQQIFS NLPVSLHCHL EQALADDLPL LKRDGGFIRS NYHKELDEMR ALRDESRRVI
     AELQAQYAQE TDIKTLKIKH NNILGYFIEI TSTQASGLTN NPQAKARFIH RQTMANAMRF
     TTTELADLES RIAHAANHAL TLELEIFDTL VQEIIEQVEF IRKAAEALAI LDVSVALAYL
     AEEQGYCRPK IDHSLTFHIT AGRHPVVEQA LRKQAAEPFV ANDCDLSVQE NQQYAAIWLL
     TGPNMGGKST FLRQNALIAI MAQMGSFVPA TSAHIGVVDR LFSRVGASDD LARGRSTFMM
     EMVETATILN HASHHSLVIL DEIGRGTSTF DGLSIAWAAV EYLHEVNHCR AILATHFHEM
     TALTEKLDRL HNVTMKVKNW DGDVVFLHEV TPGAADRSYG VQVAKLAGLP PAVITRATDV
     LHQLEQGEMA GKGHKLIDDL PLFSLKATSS LNEEKNKHDA LHEALKNIHP DELSPKQALE
     AIYHLKQLEK NNGL