ID   MUTS_BAUCH              Reviewed;         855 AA.
AC   Q1LTQ0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BCI_0209;
OS   Baumannia cicadellinicola subsp. Homalodisca coagulata.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Candidatus Baumannia.
OX   NCBI_TaxID=374463;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16729848; DOI=10.1371/journal.pbio.0040188;
RA   Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H.,
RA   Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A.;
RT   "Metabolic complementarity and genomics of the dual bacterial symbiosis of
RT   sharpshooters.";
RL   PLoS Biol. 4:1079-1092(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000238; ABF14293.1; -; Genomic_DNA.
DR   RefSeq; WP_011520397.1; NC_007984.1.
DR   AlphaFoldDB; Q1LTQ0; -.
DR   SMR; Q1LTQ0; -.
DR   STRING; 374463.BCI_0209; -.
DR   PRIDE; Q1LTQ0; -.
DR   EnsemblBacteria; ABF14293; ABF14293; BCI_0209.
DR   KEGG; bci:BCI_0209; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002427; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..855
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000071271"
FT   BINDING         617..624
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   855 AA;  95729 MW;  18FF582B048C4F89 CRC64;
     MKELTDKSIL NHTPMMQQYW QIKAQHSDVL LFYRMGDFYE LFYEDAKLAS QLIDISLTKR
     GFSAGEPIPM AGIPYHALDS YLAKLVALGK SVAICEQVGE PTINKGPVER RVVRIVTPGT
     LSDEVLLNER QDNLLAAMLQ DKQGFGYATL DITSGRFIVS EPKDFEAMAA ELQRTNPAEL
     LYPDTQHNLA LIEHRRGLRR RPIWEFELDT ACQQLMIQFG TSSLKGFGIE CAHLALRAAG
     CLLQYAKDTQ RTAMPHISTI TLERQEDYVV MDAATMRNLE LTHNLSGGIE HTLVAVLDHT
     VTSMGSRMLK RWLQMPTKHL TTIENRQQSI YFLQGKFDIL QPILRKIGDL ERILARLALR
     SARPRDLARI RNALQQLPDI QSLLADNTSG MHLSQLLSNV GYFDNLCQLL ERAIVISPSA
     LLRDGGIIAT GYNLELDELR ALANNATDYL DILEMKERKH TGLETLKIGF NAVHGYFIQL
     SREQSHRAPK RYIRRQTLKH VERYIIPELK EYEDKVITSK SKALSLEKKL YDALLDMLLP
     YLTQLQLSAT ALAELDVLSN LAERADTLHY VCPMINNQPI INIIDGRHPV VEPLMSKPFI
     ANTLSLSDQN HMIIITGPNM GGKSTYMRQN ALIVLLAYIG SFVPASQAII GPIDRIFTRI
     GAADDLVSGR STFMVEMTET ANILHNATCQ SLVLMDEIGR GTSTYDGLSL AWACAESLAS
     RIKAMTLFAT HYFELTTLPN KIKGIVNAHF AAIEYNDTIA FMHSIQNGAA NKSYGLSVAS
     LAGIPRDVIK CASRKLHELE NLSNNIALTT PLSSRSLPQF TQETSPVIQA LQEIDPDSLS
     PRQALDLLYS LKQMI