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MUTS_BORA1
ID   MUTS_BORA1              Reviewed;         875 AA.
AC   Q2KWZ4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BAV2590;
OS   Bordetella avium (strain 197N).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=360910;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=197N;
RX   PubMed=16885469; DOI=10.1128/jb.01927-05;
RA   Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D.,
RA   Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A.,
RA   Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J.,
RA   Parkhill J., Temple L.M.;
RT   "Comparison of the genome sequence of the poultry pathogen Bordetella avium
RT   with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals
RT   extensive diversity in surface structures associated with host
RT   interaction.";
RL   J. Bacteriol. 188:6002-6015(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM167904; CAJ50202.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2KWZ4; -.
DR   SMR; Q2KWZ4; -.
DR   STRING; 360910.BAV2590; -.
DR   EnsemblBacteria; CAJ50202; CAJ50202; BAV2590.
DR   KEGG; bav:BAV2590; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001977; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..875
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335119"
FT   BINDING         626..633
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   875 AA;  95242 MW;  563D7BA9638BBA1B CRC64;
     MSTVDSSSHT PMMQQYLRLK AEAGPLLLFY RMGDFYEMFY EDAEKAARLL NVTLTKRGTS
     NGAPIPMAGV PVHAMEQYLA RLVALGESVA ICEQIGDPAA AKGPVERRIV RIVTPGTLTD
     DALLPAKADR ALAAVCLSGK RDPRAGIAWL NLASGEFHVT ECAPAQLDSE LHRIGPAELV
     YADSTELDIT YSGARSRVPD WHFEADGARS HLLTHFQTDS LAGFDIEDMP VAVCAAGALL
     RYAARTQSQA LAHVQTISAE RAGMYVLMDP VTRRNLELTQ TLSGEEAPTL FSLLDDCRTP
     MGSRLLRRWL HHPLRENAPV AARQQAIATL LSARLDMAQT FGAAGLLETL RSALGLFPDI
     ERIAARLALR SVRPRELASL RDALATLPQL QTLVAPLSAS PRLAELATQL TLDPAIADLL
     SRAIAQEPAL AIRDGGVIAS GFDADLDELR LLAADSGEFL VQLEARERER TGISNLRVEF
     NRVHGFYIEV SKGQTDKVPE DYRRRQTLKN AERYITPELK SWEDKVLSAQ DRALAREKWL
     FEQVLDALSA YVRPLSDAAA ALAELDALGS LAEHARRHEW VAPDLLESAE IDIDAGRHPV
     VEHAIERFTP NHCRLDATRR MLLITGPNMG GKSTYMRQVA LIALLARTGS FVPARRARVG
     KIDRIFTRIG AADDLAGGRS TFMMEMTEAA AILAASTSNS LVLMDEIGRG TSTYDGLALA
     WAIAQRLITH NRALTLFATH YFELTRLPSE QATAANVHLA AAESAGGIVF LHEVREGPAS
     RSYGIQVAQR AGIPAAVIRH ATRELERLEA QGAPTPQLGL FAAALDAEAQ TQAQADHDAE
     NAALLALHEA LSGIDPDSLT PREALEALYR LKALQ
 
 
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