MUTS_BORA1
ID MUTS_BORA1 Reviewed; 875 AA.
AC Q2KWZ4;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BAV2590;
OS Bordetella avium (strain 197N).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Bordetella.
OX NCBI_TaxID=360910;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=197N;
RX PubMed=16885469; DOI=10.1128/jb.01927-05;
RA Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D.,
RA Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A.,
RA Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J.,
RA Parkhill J., Temple L.M.;
RT "Comparison of the genome sequence of the poultry pathogen Bordetella avium
RT with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals
RT extensive diversity in surface structures associated with host
RT interaction.";
RL J. Bacteriol. 188:6002-6015(2006).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; AM167904; CAJ50202.1; -; Genomic_DNA.
DR AlphaFoldDB; Q2KWZ4; -.
DR SMR; Q2KWZ4; -.
DR STRING; 360910.BAV2590; -.
DR EnsemblBacteria; CAJ50202; CAJ50202; BAV2590.
DR KEGG; bav:BAV2590; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_4; -.
DR OMA; TPMMAQY; -.
DR Proteomes; UP000001977; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..875
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000335119"
FT BINDING 626..633
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 875 AA; 95242 MW; 563D7BA9638BBA1B CRC64;
MSTVDSSSHT PMMQQYLRLK AEAGPLLLFY RMGDFYEMFY EDAEKAARLL NVTLTKRGTS
NGAPIPMAGV PVHAMEQYLA RLVALGESVA ICEQIGDPAA AKGPVERRIV RIVTPGTLTD
DALLPAKADR ALAAVCLSGK RDPRAGIAWL NLASGEFHVT ECAPAQLDSE LHRIGPAELV
YADSTELDIT YSGARSRVPD WHFEADGARS HLLTHFQTDS LAGFDIEDMP VAVCAAGALL
RYAARTQSQA LAHVQTISAE RAGMYVLMDP VTRRNLELTQ TLSGEEAPTL FSLLDDCRTP
MGSRLLRRWL HHPLRENAPV AARQQAIATL LSARLDMAQT FGAAGLLETL RSALGLFPDI
ERIAARLALR SVRPRELASL RDALATLPQL QTLVAPLSAS PRLAELATQL TLDPAIADLL
SRAIAQEPAL AIRDGGVIAS GFDADLDELR LLAADSGEFL VQLEARERER TGISNLRVEF
NRVHGFYIEV SKGQTDKVPE DYRRRQTLKN AERYITPELK SWEDKVLSAQ DRALAREKWL
FEQVLDALSA YVRPLSDAAA ALAELDALGS LAEHARRHEW VAPDLLESAE IDIDAGRHPV
VEHAIERFTP NHCRLDATRR MLLITGPNMG GKSTYMRQVA LIALLARTGS FVPARRARVG
KIDRIFTRIG AADDLAGGRS TFMMEMTEAA AILAASTSNS LVLMDEIGRG TSTYDGLALA
WAIAQRLITH NRALTLFATH YFELTRLPSE QATAANVHLA AAESAGGIVF LHEVREGPAS
RSYGIQVAQR AGIPAAVIRH ATRELERLEA QGAPTPQLGL FAAALDAEAQ TQAQADHDAE
NAALLALHEA LSGIDPDSLT PREALEALYR LKALQ