ID   MUTS_BORAP              Reviewed;         862 AA.
AC   Q0SM54; G0IRX9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=BAPKO_0850, BafPKo_0825;
OS   Borreliella afzelii (strain PKo) (Borrelia afzelii).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=390236;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PKo;
RX   PubMed=16914037; DOI=10.1186/1471-2164-7-211;
RA   Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J.,
RA   Wilske B., Platzer M.;
RT   "Comparative genome analysis: selection pressure on the Borrelia vls
RT   cassettes is essential for infectivity.";
RL   BMC Genomics 7:211-211(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PKo;
RX   PubMed=22123755; DOI=10.1128/jb.05951-11;
RA   Casjens S.R., Mongodin E.F., Qiu W.G., Dunn J.J., Luft B.J.,
RA   Fraser-Liggett C.M., Schutzer S.E.;
RT   "Whole-genome sequences of two Borrelia afzelii and two Borrelia garinii
RT   Lyme disease agent isolates.";
RL   J. Bacteriol. 193:6995-6996(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000395; ABH02074.1; -; Genomic_DNA.
DR   EMBL; CP002933; AEL70014.1; -; Genomic_DNA.
DR   RefSeq; WP_011601235.1; NC_017238.1.
DR   AlphaFoldDB; Q0SM54; -.
DR   SMR; Q0SM54; -.
DR   STRING; 390236.BafPKo_0825; -.
DR   EnsemblBacteria; AEL70014; AEL70014; BafPKo_0825.
DR   KEGG; baf:BAPKO_0850; -.
DR   KEGG; bafz:BafPKo_0825; -.
DR   PATRIC; fig|390236.22.peg.786; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_12; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000005216; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..862
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008047"
FT   BINDING         608..615
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   862 AA;  99871 MW;  37FC1B106995EAD0 CRC64;
     MEKNVTPMMR QYLDIKKKYK DAIIFFRVGN FYEMFFDDAI EASKLLNLTL TKRENVPMCG
     VPYHTSKEYI RKLILFDKKV AICEQAANST SVGPLEREVV EVITPGVIVD EDFLNDDVNN
     YLVAISDYKN YYSFSYIDLS TSSLGIMFYE NSFFEKLKRD LEKYSPKEII VSENFYYEYS
     EKLNLNRFLI NRVPAWHLDK DVAIKTIKEH FNILGLSSLG FDEEKPYYIS IFLIINHIKN
     NLKNLLSNID KIDINNDSLY MFLDDVTQVN LELVKNNNDF SSQYSLYSVL NDCKTAMGKR
     LLREFILNPI LNIPEINTRL DHVEFFCKNI SLTMTLREAF VNIWDVERII SRIQMKRYIK
     KDFLFIEKSL SVFFLVKKLF DKHNFDYWNF DKFEEDSISK VYFLINSAIS SSSDELIKRG
     YDLKLDSLKD LKINANKYID EYLESERLLS KINNLKIRKT NNRGLFFEVT KSNYAQVPPH
     FMESQTLNSS KRYKTEKLIS LEANINNAED SVVAFEQEIF DEIASNVVKH NKVLKKVAEF
     FAYIDLVVNF GYLAKKNEYK RPILTCSKEI FLEKSRHPVV EHYVKNTEIF TENFVKINKE
     KYFCLITGPN MAGKSTYLRQ VALITLMAHI GSFVPASRAV IGITDKIFCR IGASDNLAKG
     ESTFLVEMNE TANILRNATE KSLIIMDEVG RGTSTNDGLA IAYSIIEYIL EYIKARSLFA
     THFHELSAIN HKAFINLSMK IEKQGNELVF LREVEEKPSL NSYGIYVARI AGLPLRVVDR
     ANVILKSLGS RKDSSCLEFL PCISSDTCDR EVLKNDTDVH VKLNEYLELK KFISNIDINN
     ITPFQSIELL NQLVLKVISQ SS