ID   MUTS_BORBR              Reviewed;         876 AA.
AC   Q7WLT5;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BB1660;
OS   Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
OS   (Alcaligenes bronchisepticus).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-588 / NCTC 13252 / RB50;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAE32157.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BX640442; CAE32157.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_010926220.1; NC_002927.3.
DR   AlphaFoldDB; Q7WLT5; -.
DR   SMR; Q7WLT5; -.
DR   STRING; 257310.BB1660; -.
DR   EnsemblBacteria; CAE32157; CAE32157; BB1660.
DR   KEGG; bbr:BB1660; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001027; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..876
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115072"
FT   BINDING         626..633
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   876 AA;  95568 MW;  00D0A0E157159320 CRC64;
     MSQVIDSKHT PMMQQYLRLK AEAGPLLLFY RMGDFYEMFY EDAERAARLL NLTLTKRGNS
     NGTPIPMAGI PVHAMEQYLA RLVALGESVA ICEQIGDPAA AKGPVERRIV RIVTPGTLTD
     EALLPAKADR ALAAVCVTGK REPRAGLAWL NLASGAFHVT ECAPGQLESE LHRIAPAELI
     QAESAELHMA FEGARTRVPD WHFEADGARA QLLAHFKTDS LGGFDVEDMP AAVCAAGALL
     RYAARTQSQA LAHVQTIAAE RPGQYVLLDP VTRRNLELTQ TLSGEESPTL FSLLDGCRTP
     MGSRLLRRWL HHPLRENEPV LARQHAIATM LTARQEGEQA FAAAALLETL RDALNAFPDI
     ERIAARVALR SVRPRELASL RDALVALPAL HASLAPLSGS PRARELAAQL AMPPDIGELL
     ARAVASEPAV AIRDGGVIAA GFDSELDELR ALATDGGDFL VQLEARERER TGIGNLRVEF
     NRVHGFYIEV SKGQTDKVPE DYRRRQTLKN AERYITPELK TWEDRVLSAQ DRSLAREKWL
     YEQLLDALAQ YVRPLSQCAS ALAELDTLAA LAEHARRHDW VAPELIDGAE IDIEAGRHPV
     VERAIERFTP NGCRLDQTRR MLLITGPNMG GKSTYMRQVA LIALLARTGS FVPATRARVG
     RLDRIFTRIG AADDLAGGRS TFMMEMTEAA AILAASTPAS LVLMDEIGRG TSTYDGLALA
     WAIAYRLLTH NRALTLFATH YFELTRLPAE QPTAANVHLA AAESAGGIVF LHEVREGPAS
     RSYGIQVAQR AGVPAAVIRQ ASRELERLEA QGAPTPQLGL FAAALDADVQ SQAMTEQAED
     AAALAQLRDQ LAAIDPDSLT PREALDALYR LKQHLT