ID   MUTS_BORBZ              Reviewed;         862 AA.
AC   B7J0P3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BbuZS7_0827;
OS   Borreliella burgdorferi (strain ZS7) (Borrelia burgdorferi).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=445985;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ZS7;
RX   PubMed=20935092; DOI=10.1128/jb.01158-10;
RA   Schutzer S.E., Fraser-Liggett C.M., Casjens S.R., Qiu W.G., Dunn J.J.,
RA   Mongodin E.F., Luft B.J.;
RT   "Whole-genome sequences of thirteen isolates of Borrelia burgdorferi.";
RL   J. Bacteriol. 193:1018-1020(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001205; ACK75100.1; -; Genomic_DNA.
DR   RefSeq; WP_002657221.1; NC_011728.1.
DR   AlphaFoldDB; B7J0P3; -.
DR   SMR; B7J0P3; -.
DR   EnsemblBacteria; ACK75100; ACK75100; BbuZS7_0827.
DR   GeneID; 56567376; -.
DR   KEGG; bbz:BbuZS7_0827; -.
DR   HOGENOM; CLU_002472_3_1_12; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000006901; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..862
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000117281"
FT   BINDING         608..615
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   862 AA;  99749 MW;  513B2FD6A831BFE9 CRC64;
     MEKNVTPMIR QYLDIKKKYK DAVLFFRVGS FYEMFFDDAI EVSKLLNLTL TKRENVPMCG
     VPYHTSKEYI RKLILFDKKV AICEQASNST SGGPLEREVV EVITPGVIID EDFLNDDINN
     YLVAISDYKD YYSFSYIDLS TSSLGIMFYE NGFFEKLKRD LEKYSPKEII VSENFYYEYS
     EKLNLSRFLI NRVPTWHLDK DIAIKTIKEH FNILGLSSLG FDEEKPYYIS IFLIINHIKN
     NLKNLLSNID KIDINNDSSY MFLDDVTQVN LELVKNNNDF SSQYSLYSVL NDCKTAMGKR
     LLREFILNPI LNISEINTRL DHVEFFCKNI SLTVTLRETF INIWDIERII SRIQMKRYIK
     KDFLFIEKAL SVFFTVKKLF DKHNFDYWNF DKFEEDSISK VYFLINSAIS SAPDELIKRG
     YDLKLDNLKD LKINANKYID QYLESERLLS KINNLKIRKT NNRGLFFEVT KSNYAQVPPH
     FMESQALNSS KRYKTEKLIS LEVDINNAED NVVAFEQEIF DEIASNVVMH NKVLKKVAEF
     FAYIDLVVNF GYLAKKNEYK RPVLTSGKEI LLEKSRHPVV EHYTKNTEIF TENFVRINKE
     KYFCLITGPN MAGKSTYLRQ VALITLMAHI GSFVPASKAL IGITDKIFCR IGASDNIAKG
     ESTFLVEMNE TANILRNATE KSLIIMDEVG RGTSTNDGLA IAYSIIEYIL EYIKARSLFA
     THFHELSSIN HQAFINLSMK IEKQGNDLVF LREVEEKPSL NSYGIYVARI AGLPLRVIDR
     ANVILESLVG REGNSCLEFL PHVSSDGNDK EILKNDTDIH IKLNEYLELK NFISNIDINN
     ITPFQSIELL NQIVLKVISQ SS