ID   MUTS_BORGP              Reviewed;         862 AA.
AC   Q65ZX6;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BG0823;
OS   Borrelia garinii subsp. bavariensis (strain ATCC BAA-2496 / DSM 23469 /
OS   PBi) (Borrelia bavariensis).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=290434;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-2496 / DSM 23469 / PBi;
RX   PubMed=15547252; DOI=10.1093/nar/gkh953;
RA   Gloeckner G., Lehmann R., Romualdi A., Pradella S., Schulte-Spechtel U.,
RA   Schilhabel M., Wilske B., Suehnel J., Platzer M.;
RT   "Comparative analysis of the Borrelia garinii genome.";
RL   Nucleic Acids Res. 32:6038-6046(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000013; AAU07645.1; -; Genomic_DNA.
DR   RefSeq; WP_011194090.1; NZ_CP028872.1.
DR   AlphaFoldDB; Q65ZX6; -.
DR   SMR; Q65ZX6; -.
DR   STRING; 290434.BG0823; -.
DR   PRIDE; Q65ZX6; -.
DR   EnsemblBacteria; AAU07645; AAU07645; BG0823.
DR   KEGG; bga:BG0823; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_12; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002276; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..862
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224353"
FT   BINDING         608..615
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   862 AA;  99912 MW;  562F86AB8111BB5D CRC64;
     MEKNITPMMR QYLDIKKKYK DAIIFFRVGS FYEMFFDDAI EASKLLNLTL TKRENVPMCG
     VPYHTSKEYI RKLILFDKKV AICEQASNLT STGPLEREVV EVITPGVIVD EDFLNDDVNN
     YLVAISDYKN YYSFSYIDLS TSSLGVMFYE NSFFEKLKRD LEKYSPKEII VSENFYYQYL
     HKLNLSRFLI NRVPAWHLDK DIAIKTIKEH FNILGLSSLG FDEEKPYYIS IFLIINHIKN
     NLKNLLSNID KIDINNDSSY MFLDDVTQVN LELVKNNNDF SSQYSLYSVL NDCKTAMGKR
     LLREFILNPI LNISEINTRL DHVEFFYKNI SLTMTLREAF INIWDIERII SRIQMKRYIK
     KDFLFIEKAL SVFFLVKKLF DKHNFDYWNF DKFEEDSVSK VYFLINSAIS DSSDELIKRG
     YDLKLDNLKD LKINANKYID EYLESERILS KINNLKIRKT NNRGLFFEVT KSNYSQVPSH
     FMESQTLSSS KRYKTEKLIS LEVDINNAED SVVAFEQEIF DEIAANVVKH NKVLKKVAEF
     FAYIDLVVNF GYLAKKNEYK RPVLTSDKEI FLDKSRHPVV EHYVKNAEIF TENFVRINKE
     RHFCLITGPN MAGKSTYLRQ VALITLMAHI GSFVPASKAL IGITDKIFCR IGASDNLAKG
     ESTFLVEMNE TANILRNATE KSLIIMDEVG RGTSTNDGLA IAYSIIEYIL EYIKARSLFA
     THFHELSAIN HKAFINLSMK IEKQGNDLVF LREIEEKPSL NSYGIYVARI AGLPLKVIDR
     ANAILESLLS RKGSSFLEFL PYISSDSNDK EALKNDTDVN VKLNEYLELK NFISNIDINN
     ITPFQSIELL NQIVLKVISQ SS