ID   MUTS_BORHD              Reviewed;         861 AA.
AC   B2S1E1;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BH0797;
OS   Borrelia hermsii (strain HS1 / DAH).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=314723;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HS1 / DAH;
RA   Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T.,
RA   Schwan T.G.;
RT   "The genome sequence of Borrelia hermsii and Borrelia turicatae:
RT   comparative analysis of two agents of endemic N. America relapsing fever.";
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000048; AAX17294.1; -; Genomic_DNA.
DR   RefSeq; WP_012422544.1; NC_010673.1.
DR   AlphaFoldDB; B2S1E1; -.
DR   SMR; B2S1E1; -.
DR   KEGG; bhr:BH0797; -.
DR   HOGENOM; CLU_002472_3_1_12; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..861
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093608"
FT   BINDING         609..616
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   861 AA;  99281 MW;  1D5AFEB7C2F5B757 CRC64;
     MKKDVTPMMR QYLSIKNKHK DAILFFRVGS FYEMFFDDAL EGSKLLGLTL TKREDIPMCG
     VPCHTSKEYI KKLILLDRKV AICEQGGVQT DPKGPLEREV VEVISPGVVV DEDFLQDDVN
     NYLVAISDYK DYYSFSYIDL STSRLGIILY EGSFLEKLRR DIEKYSPKEI IVSESFYYKY
     LEKLALDRFL VNKVPHWHLD KDIAIKSLKD HFNVLSLSAF GFKEDEPYYI SSFLIIDYIK
     NNLKNLLINI DTIYINSDSE YMFLDDVTQI NLELVKNNND LTARYSLYSV LNDCKTPMGK
     RLLREYILNP LLDIAAINNR LDHVEFLNNN VNLSIKLREI LSNVWDIERI ISRLQMRKYA
     KKDFLFIRET LIAFFSVKRL LNEYSFNYWI FDVNDEGDIR GIYSLIDCAI SNEQDELIKQ
     GYNSEIDRLR ELKNNASKYV DDYLDFERNF SKINSLKIKR INVRGLFFEV TKSYYGQVPS
     HFIESQTLNS VKRYKTNKLI ELERDINDAE DNLLSLEQEI FDEIALKVVK YSTVIKKVAE
     FCAYIDVVSN FAYLAKKNEY VRPTLTNNKE IILECARHPV VEHYMKGVEA FTRNSVRIDG
     EKYFCLITGP NMAGKSTYLR QTALVVLMGH IGSFVPANKA IIGITDKIFC RIGASDNISK
     GESTFLVEMN ETANILRNAT QDSLIIMDEV GRGTSTNDGL AIACSIVEYI LEDIKARSLF
     ATHFHELSAI NHDSFVNLSM KIERQGNELI FLREVEEKPS LNSYGIYVAR IAGIPLKVIK
     RANIILKSLT SRENLCVSEF FTSATSVVND GEDTMEEDLS YELDLNAYLE LKNLISKIDI
     NNITPFQAMN LLSEIILKTK M