ID   MUTS_BORPA              Reviewed;         883 AA.
AC   Q7W880;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 2.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BPP2265;
OS   Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257311;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12822 / ATCC BAA-587 / NCTC 13253;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAE37563.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BX640429; CAE37563.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q7W880; -.
DR   SMR; Q7W880; -.
DR   EnsemblBacteria; CAE37563; CAE37563; BPP2265.
DR   KEGG; bpa:BPP2265; -.
DR   HOGENOM; CLU_002472_3_1_4; -.
DR   Proteomes; UP000001421; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..883
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115074"
FT   BINDING         633..640
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   883 AA;  96140 MW;  205150A8C9B085CE CRC64;
     MSSTPKQTTG DALAGHTPMM QQYLRLKAEA GPLLLFYRMG DFYEMFYEDA ERAARLLNLT
     LTKRGNSNGT PIPMAGIPVH AMEQYLARLV ALGESVAICE QIGDPAAAKG PVERRIVRIV
     TPGTLTDEAL LPAKADRALA AVCVTGKREP RAGLAWLNLA SGAFHVTECA PGQLESELHR
     IAPAELIQAE SAELHMAFEG ARTRVPDWHF EADGARAQLL AHFKTDSLGG FDVEDMPAAV
     CAAGALLRYA ARTQSQALAH VQTIAAERPG QYVLLDPVTR RNLELTQTLS GEESPTLFSL
     LDGCRTPMGS RLLRRWLHHP LRENEPVLAR QHAIATMLTV RQEGEQAFAA AGLLETLRDA
     LNAFPDIERI AARVALRSVR PRELASLRDA LVALPALHAS LAPLSGSPRA RELAAQLAMP
     PDIGELLARA VASEPAVAIR DGGVIAAGFD SELDELRALA TDGGDFLVQL EARERERTGI
     GNLRVEFNRV HGFYIEVSKG QTDKVPEDYR RRQTLKNAER YITPELKTWE DRVLSAQDRS
     LAREKWLYEQ LLDALAQYVR PLSQCASALA ELDTLAALAE HARRHDWVAP ELIDGAEIDI
     EAGRHPVVER AIERFTPNGC RLDQTRRMLL ITGPNMGGKS TYMRQVALIA LLARTGSFVP
     ATRARVGRLD RIFTRIGAAD DLAGGRSTFM MEMTEAAAIL AASTPASLVL MDEIGRGTST
     YDGLALAWAI AYRLLTHNRA LTLFATHYFE LTRLPAEQPT AANVHLAAAE SAGGIVFLHE
     VREGPASRSY GIQVAQRAGV PAAVIRQASR ELERLEAQGA PTPQLGLFAA ALDADVQSQA
     MTEQAEDAAA LAQLRDQLAA IDPDSLTPRE ALDALYRLKQ HLT