ID   MUTS_BORPE              Reviewed;         883 AA.
AC   Q7VY01;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BP1566;
OS   Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX640415; CAE41855.1; -; Genomic_DNA.
DR   RefSeq; NP_880300.1; NC_002929.2.
DR   AlphaFoldDB; Q7VY01; -.
DR   SMR; Q7VY01; -.
DR   STRING; 257313.BP1566; -.
DR   KEGG; bpe:BP1566; -.
DR   PATRIC; fig|257313.5.peg.1681; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002676; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..883
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115075"
FT   BINDING         633..640
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   883 AA;  96190 MW;  C2F6F7539C1EB53C CRC64;
     MSSTPKQTTG DALAGHTPMM QQYLRLKAEA GPLLLFYRMG DFYEMFYEDA ERAARLLNLT
     LTKRGNSNGT PIPMAGIPVH AMEQYLARLV ALGESVAICE QIGDPAAAKG PVERRIVRIV
     TPGTLTDEAL LPAKADRALA AVCVTGKREP RAGLAWLNLA SGAFHVTECA PAQLESELHR
     IAPAELIQAE SAELHMAFEG ARTRVPDWHF EADGARAQLL AHFKTDSLGG FDVEDMPAAV
     CAAGALLRYA ARTQSQALAH VQTIAAERSG QYVLLDPVTR RNLELTQTLS GEESPTLFSL
     LDGCRTPMGS RLLRRWLHHP LRENEPVLAR QHAIATMLTA RQEGEQTFAA AGLLETLRDA
     LNAFPDIERI AARVALRSVR PRELASLRDA LAALPALHAS LTPLSGSPRA RELAAQLAMP
     PDIGELLARA VASEPAVAIR DGGVIAAGFD SELDELRALA TDGGDFLVQL EARERERTGI
     GNLRVEFNRV HGFYIEVTKG QTDKVPEDYR RRQTLKNAER YITPELKTWE DRVLSAQDRS
     LAREKWLYEQ LLDALAQYVR PLSQCASALA ELDTLAALAE HARRHDWVAP ELIDGAEIDI
     EAGRHPVVER AIERFTPNGC RLDQTRRMLL ITGPNMGGKS TYMRQVALIA LLARTGSFVP
     ATRARVGRLD RIFTRIGAAD DLAGGRSTFM MEMTEAAAIL AASTPASLVL MDEIGRGTST
     YDGLALAWAI AYRLLTHNRA LTLFATHYFE LTRLPAEQPT AANVHLAAAE SAGGIVFLHE
     VREGPASRSY GIQVAQRAGV PAAVIRQASR ELERLEAQGA PTPQLGLFAA ALDADVQSQA
     MTEQAEDAAA LAQLRDQLVA IDPDSLTPRE ALDALYRLKQ HLT