ID   MUTS_BORT9              Reviewed;         860 AA.
AC   A1R0M2;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BT0797;
OS   Borrelia turicatae (strain 91E135).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=314724;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91E135;
RA   Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T.,
RA   Schwan T.G.;
RT   "The genome sequence of Borrelia hermsii and Borrelia turicatae:
RT   comparative analysis of two agents of endemic N. America relapsing fever.";
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000049; AAX18113.1; -; Genomic_DNA.
DR   RefSeq; WP_011772731.1; NC_008710.1.
DR   AlphaFoldDB; A1R0M2; -.
DR   SMR; A1R0M2; -.
DR   STRING; 314724.BT0797; -.
DR   KEGG; btu:BT0797; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_12; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001205; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..860
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000192198"
FT   BINDING         608..615
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   860 AA;  99641 MW;  56D57ADF5AC38C62 CRC64;
     MRKDVTPMMR QYLNIKDKHK DAILFFRVGS FYEMFFDDAL EGSKLLGLTL TKRENVPMCG
     VPCHTSKDYI KKLILLDKKV AICEQGLQTD PKGPLEREVV EVISPGVVID EDFLQDDINN
     YLIAISDYKD YYSFSYIDLS TSRLGIILYE GNFLEKLRRD IEKYSPKEII VSEDFYYEYL
     EKLALDRFLV NKIPHWHFDK EIAMKSLKEH FNVLSLSALG FKEDEPYYVS SFLIIDYIKN
     NLKNLLINID TIHINNDSEY MFLDDVTQIN LELVKNNNDL TSCYSLYSVL NDCKTPMGKR
     LLREYILNPL LDIVAINNRL DHVEFLNNNI NLSMKLRDIL SNVWDIERII SRLQMKKYVK
     KDFLLIKESL TAFFLAKRLL NEHSFSYWIF DVNDENNIRE IYSLIDCSIS KEPDELIQHG
     YNFEIDRLRE IKNNASKYVD DYLNFERNFS KISSLKIRRI NVRGLFFEVT KSYYGQVPSH
     FIESQTLNSV KRYKTNKLIE LERDINDAED NLLALEQEVF DDIASKIVKH SVVIKKIANF
     FAYVDVVSDF AYLAKKNEYV RPTLTNNKEI ILECSRHPVV EHYMKGVEAF TKNSVKIDND
     KYFCLITGPN MAGKSTYLRQ TALVVLMGHI GSFVPANQAI IGITDKIFCR IGASDNISKG
     ESTFLVEMNE TANILRNATQ NSLIIMDEVG RGTSTNDGLA IAYSIVEYIL EHIQARSLFA
     THFHELSAIK HDSFVNLSMK IERQGDELIF LREVEEKPSL NSYGIYVARI AGIPLKVIER
     ANVILKSLTS REHLYVPEFF TSATLVINDG EEAMKEDLSY ELELNDYLEL KNFISKIDVN
     NITPFQAMNL LSEIILKTKT