ID   MUTS_BRADU              Reviewed;         912 AA.
AC   Q89VX1;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=bll0924;
OS   Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS   NBRC 14792 / USDA 110).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=224911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA   Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000040; BAC46189.1; -; Genomic_DNA.
DR   RefSeq; NP_767564.1; NC_004463.1.
DR   RefSeq; WP_011083746.1; NZ_CP011360.1.
DR   AlphaFoldDB; Q89VX1; -.
DR   SMR; Q89VX1; -.
DR   STRING; 224911.27349174; -.
DR   EnsemblBacteria; BAC46189; BAC46189; BAC46189.
DR   GeneID; 64020787; -.
DR   KEGG; bja:bll0924; -.
DR   PATRIC; fig|224911.44.peg.312; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   InParanoid; Q89VX1; -.
DR   OMA; TPMMAQY; -.
DR   PhylomeDB; Q89VX1; -.
DR   Proteomes; UP000002526; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..912
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115076"
FT   BINDING         661..668
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   912 AA;  97983 MW;  E1EA85780D31643A CRC64;
     MTMQQPIPVP PPDETPAPQA EAAARVTPMM EQYLEIKAAH QGLLLFYRMG DFYELFFEDA
     EIASKTLGIV LTKRGKHQGA DIPMCGVPVE RAEDYLHRLI SAGHRVAVCE QTEDPAAAKA
     RGNKSVVRRG VVRLVTPGTL TEDTLLDARA NNYLLAIARA RSSTGGDRFG LAWIDISTAE
     FMVTECSGGE LAATLARINP NEAIVTDALY NDNELGQTLR ELPAVTPLTR DVFDGATAEK
     RLCDYFAVAT MDGLAQLTRL EATAASAAVT YVDRTQVGRH PPLSPPAREA SGATMAIDPA
     TRANLELTRT LAGERRGSLL DAIDCTVTSA GSRLLAQRLA APLTDAPAIA RRLDAVGAFV
     ADSAAREDIR SILRGAPDMS RALARLSVGR GGPRDLAGLR DGIIAADQVL ARLGELDQPP
     QEIAAVMAAL TRPSRELAAE FATALDEQLP LIKRDGGFVR QGYEPALDEA RNLRDASRLV
     VASMQARYAD DTGVKGLKIR HNNVLGYFVE VTAQHGDKLM SAPLNATFIH RQTLAGQIRF
     TTSELGEIEA KIANAGDRAL GLELEIFERL CAKALEISDD LRAAAQGFAL LDVATSLAKL
     AVDENYVRPE VDSSLGFAIE AGRHPVVEQA LKRNGEPFIA NACDLSPAPA QKSGQLWLLT
     GPNMAGKSTF LRQNALIALL AQIGSFVPAT RARIGIIDRL FSRVGAADDL ARGRSTFMVE
     MVETAAILNQ AGERALVILD EIGRGTATFD GLSIAWAAIE HLHESNRCRT LFATHYHELT
     ALSAKLPRMF NATVRVKEWQ GNVVFLHEVL PGSADRSYGI QVAKLAGLPP AVITRAKSVL
     AKLEAQDRGQ TARALADDLP LFAVPSRAAA EAAPPSEAEL LMDAVKALHP DEMSPREALD
     ALYALKAKLP KQ