ID   MUTS_BRASB              Reviewed;         910 AA.
AC   A5ETJ3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BBta_7642;
OS   Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium; unclassified Bradyrhizobium.
OX   NCBI_TaxID=288000;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BTAi1 / ATCC BAA-1182;
RX   PubMed=17540897; DOI=10.1126/science.1139548;
RA   Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C.,
RA   Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA   Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z.,
RA   Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.-S., Saunders E.,
RA   Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G.,
RA   Emerich D., Vermeglio A., Medigue C., Sadowsky M.;
RT   "Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.";
RL   Science 316:1307-1312(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000494; ABQ39487.1; -; Genomic_DNA.
DR   RefSeq; WP_012047378.1; NC_009485.1.
DR   AlphaFoldDB; A5ETJ3; -.
DR   SMR; A5ETJ3; -.
DR   STRING; 288000.BBta_7642; -.
DR   EnsemblBacteria; ABQ39487; ABQ39487; BBta_7642.
DR   KEGG; bbt:BBta_7642; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000246; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..910
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335120"
FT   BINDING         659..666
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   910 AA;  97928 MW;  9DCDFF10C263364F CRC64;
     MTIQQPITAP VPQETAPAEA PAKLTPMMEQ YLDIKAAHPG LMLFYRMGDF YELFFEDAEV
     ASKALGIVLT KRGKHQGQDI PMCGVPVERS EDYLHRLIAQ GIRVAVCEQM EDPAAARARG
     NKSVVKRGVV RVVTPGTLTE DNLLDARANN YLLAIARSRG SSGGDRLGLA WIDISTSDFI
     VTECAFAELT ATLARINPNE VIISDALYSD EVFEPVLREL AAVTPLTRDV FDGATAERRL
     CDYFAVATMD GLAVLSRLET TAAAACVTYV ERTQVGQRPP LAPPAREATG STMAIDPATR
     ANLELTRTLA GERRGSLLDA IDCTVTSAGS RLLAQRLAAP LTEPAQIGRR LDAVNVFVAD
     SAAREDIRAI LRGAPDMTRA MARLSVGRGG PRDLAALRDG ILAADQALGR LSALDQPPQE
     IAAAMAALAR PARALAEELS RALDEQLPLI KRDGGFVRSG YDSTLDETRN LRDASRLVVA
     SMQARYADQT GVKALKIRHN NVLGYFVEVT AQHGDKLMSA PLNATFIHRQ TLAGQVRFTT
     SELGEIEAKI ANAGERALNL ELEIFDRLCG QALAIGDDLR AAAHGFAMLD VATALAKLAV
     DDNYIRPEVD GSLGFAIEGG RHPVVEQALK REGQPFIANS CDLSPTPGHK SGQLWLLTGP
     NMAGKSTFLR QNALIALLAQ IGSFVPATRA RIGIVDRLFS RVGAADDLAR GRSTFMVEMV
     ETAAILNQAG ERALVILDEI GRGTATFDGL SIAWAAIEHL HESNRCRTLF ATHYHELTAL
     AAKLPRLFNA TVRVKEWHGD VVFLHEVLPG SADRSYGIQV AKLAGLPPAV ISRAKSVLAK
     LEAADRGQNA RALVDDLPLF AVPSRAAPEP AMSKEAEELI AAVKALHPDE MTPREAMDAL
     YALKAKLPKG