ID   MUTS_BRASO              Reviewed;         916 AA.
AC   A4YKQ0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BRADO0537;
OS   Bradyrhizobium sp. (strain ORS 278).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium; unclassified Bradyrhizobium.
OX   NCBI_TaxID=114615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ORS 278;
RX   PubMed=17540897; DOI=10.1126/science.1139548;
RA   Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C.,
RA   Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA   Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z.,
RA   Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.-S., Saunders E.,
RA   Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G.,
RA   Emerich D., Vermeglio A., Medigue C., Sadowsky M.;
RT   "Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.";
RL   Science 316:1307-1312(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CU234118; CAL74476.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4YKQ0; -.
DR   SMR; A4YKQ0; -.
DR   STRING; 114615.BRADO0537; -.
DR   EnsemblBacteria; CAL74476; CAL74476; BRADO0537.
DR   KEGG; bra:BRADO0537; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001994; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..916
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335121"
FT   BINDING         665..672
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   916 AA;  98788 MW;  BEC7B725D4B5BF4A CRC64;
     MASFRAMTIQ QPISVPVPQE ATPAEAPAKL TPMMEQYLDI KAAHPGLMLF YRMGDFYELF
     FEDAEVASKA LGIVLTKRGK HQGQDIPMCG VPVERSEDYL HRLIAQGIRV AVCEQMEDPA
     AARARGNKSV VKRGVVRVVT PGTLTEDNLL DARANNYLLS IARSRGSSGG DRLGLAWIDI
     STSDFIVTEC AFAELTATLA RINPNEVIVS DALYSDEAFE PVLRELAAVT PLTRDVFDGA
     TAERRLCDYF AVATMDGLAV LSRLEATAAA ACVTYVERTQ VGQRPPLAPP AREATGSTMA
     IDPATRANLE LTRTLAGERR GSLLDAIDCT VTSAGSRLLA QRLAAPLTEP AQIGRRLDAV
     NAFVADSAAR EDIRVILRGA PDMTRAMARL SVGRGGPRDL AALRDGILAA DQALARLSVL
     DQPPQEIASV MAALARPARA LADEFARALD EQLPLIKRDG GFVRSGYDAT LDETRNLRDA
     SRLVVASMQA RYADQTGVKA LKIRHNNVLG YFVEVTAQHG DKLMSAPLNA TFIHRQTLAG
     QVRFTTSELG EIEAKIANAG ERALNLELEI FDRLCAQALA IGDDLRAAAH GFAMLDVATA
     LAKLALDDNY VRPEVDGSLG FAIEGGRHPV VEQSLKREGQ PFIANSCDLS PTPGHKSGQL
     WLLTGPNMAG KSTFLRQNAL IALLAQIGSF VPASRARIGI VDRLFSRVGA ADDLARGRST
     FMVEMVETAA ILNQAGERAL VILDEIGRGT ATFDGLSIAW AAIEHLHESN RCRTLFATHY
     HELTALAAKL PRLFNATVRV KEWQGDVVFL HEVLPGSADR SYGIQVAKLA GLPPAVISRA
     KSVLAKLEAA DRGQNARALV DDLPLFAVPS RAAVEPAMSK ETEELIAAVK DLHPDEMTPR
     EALDALYRLK AKLPAK