ID   MUTS_BREBN              Reviewed;         862 AA.
AC   C0ZEZ4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BBR47_33760;
OS   Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus.
OX   NCBI_TaxID=358681;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=47 / JCM 6285 / NBRC 100599;
RA   Hosoyama A., Yamada R., Hongo Y., Terui Y., Ankai A., Masuyama W.,
RA   Sekiguchi M., Takeda T., Asano K., Ohji S., Ichikawa N., Narita S.,
RA   Aoki N., Miura H., Matsushita S., Sekigawa T., Yamagata H., Yoshikawa H.,
RA   Udaka S., Tanikawa S., Fujita N.;
RT   "Brevibacillus brevis strain 47, complete genome.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AP008955; BAH44353.1; -; Genomic_DNA.
DR   RefSeq; WP_015891660.1; NC_012491.1.
DR   AlphaFoldDB; C0ZEZ4; -.
DR   SMR; C0ZEZ4; -.
DR   STRING; 358681.BBR47_33760; -.
DR   EnsemblBacteria; BAH44353; BAH44353; BBR47_33760.
DR   KEGG; bbe:BBR47_33760; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001877; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..862
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000192199"
FT   BINDING         604..611
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   862 AA;  96465 MW;  68A6EB8DAF552771 CRC64;
     MAQYTPMIQQ YLAIKKDYPD TFLFFRLGDF YELFFDDAIL ASRELEITLT GRDGGGSERI
     PMCGVPHHAA DGYIAELLKK GHKVAVCEQV EDPKEAKGVV RREVTRVITP GTMMEGKWLT
     DKENNYMAAL AQVEGRTGVA ACDMSTGEMY VTSLAGQAES VLDEALQYRP KELVFFGLAA
     LPKTALPSTV VDAHQLDVFA VDSQYAEQAK GLDVSMRAAV NALLFYIGTT QKRSLAHMRL
     LKQYDAKQYL QMDGFSRRNL ELTETIRDKT KKGSLLWLLD RTQTAMGGRL LRRWIERPLL
     SRDQLEARLS AVEALKGDML LRSDLRTCLD RVYDLERLAG RISYGNANAR DLIQLRMSLE
     AVPELKQYMI QTNTPVLMEL ANGMDECADI VNYLAHALVD DPPISVREGG MIRTGYDEYL
     DKLHTASREG KTWIAQLEQG EREATGIRSL KVGFNKVFGY YIEISKSNIA NVPAGRYERK
     QTLANAERYI TPELKEREAL ILEAEEKMIE LEYQLFVAVR SEVAKHIPRL QNLAERIASV
     DVLQAFATVS DERGFVRPEL VESGDYVITE GRHPVVEAVL EREKYVANDV EMDQTNRQVL
     LITGPNMAGK STYMRQIALI TVMAQIGCFV PAKQAKLSIV DQIFTRIGAA DDLVGGHSTF
     MVEMLETRHA LQKATAKSLI LLDEIGRGTS TYDGMALAQA VIEYICQKIG AKTLFSTHYH
     ELTGLAETLS GVVNVNARCE EREGKLLFLH KIEEGRADKS YGIHVAELAE MPTWVIERAR
     SILTGLEANG STGNGNAASD VQMSLETLWT APVAAVREEP MQFASAEEEA IMAELRELDL
     NSTTPMDAMM KLYAWKQQLK KR