ID   MUTS_BRUC2              Reviewed;         910 AA.
AC   A9M792;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BCAN_A0152;
OS   Brucella canis (strain ATCC 23365 / NCTC 10854).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=483179;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23365 / NCTC 10854;
RA   Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C.,
RA   Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S.,
RA   Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M.,
RA   Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H.,
RA   Bruce D., Detter C., Munk C., Brettin T.S.;
RT   "Brucella canis ATCC 23365 whole genome shotgun sequencing project.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000872; ABX61251.1; -; Genomic_DNA.
DR   RefSeq; WP_004691341.1; NC_010103.1.
DR   AlphaFoldDB; A9M792; -.
DR   SMR; A9M792; -.
DR   EnsemblBacteria; ABX61251; ABX61251; BCAN_A0152.
DR   GeneID; 45051291; -.
DR   GeneID; 55589938; -.
DR   KEGG; bcs:BCAN_A0152; -.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   PhylomeDB; A9M792; -.
DR   Proteomes; UP000001385; Chromosome I.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..910
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335123"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         658..665
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   910 AA;  98836 MW;  CEDAE84737E3477A CRC64;
     MEAKVEEKEP EPVENAGPDA PVRLTPMMEQ YIEIKAANVD SLLFYRMGDF YELFFDDAVA
     ASAALGITLT KRGKHLGEDI PMCGVPVHAA DDYLQKLIAK GYRVAVCEQV EDPAEAKKRG
     SKSVVKRDVI RLVTPGTLTE EKLLDPAQAN FLMAMGRTRG DGALALAWID ISTGTFRVAE
     TTPDRLFADI MRVDPRELVV ADSAFHDEEL RPVFDLIGKA VTPQPATLFD SAAAQTRIQH
     YFNVATLDGF GQFSRPELSA ISGAIAYIEK TQISERPPLM RPEREHEGGT LFIDPATRAS
     LELARTMSGN RDGSLLKAID RTVTGGGARL LAERLTAPLT SPKEIALRLD SVSWCLSEQT
     LCEALRLELK GVPDMPRALS RLAVGRGGPR DLGALACGFE AAGGIASLLD GALLPDELAA
     AREAIEKMPA GFAAHLDRAL ADELPLLKRD GGFVREGYNS ELDEMRALRD QSRRVIAGLQ
     ADYIEETGIK SLKIKHNNVL GYFIEVTANN SGAMTDTDEA KSRFIHRQTM ANAMRFTTTE
     LAELESKIAN AADRALSIEL AIFEELTAEA VAHADSIRAA ASALSVFDVS TALAVLAEER
     GYCRPHVDDS LSFNIVAGRH PVVEQALRRQ AANPFVANDC DLSPQRDGGD GAIWLLTGPN
     MGGKSTFLRQ NALIAILAQM GSFVPAGSAH IGVVDRLFSR VGASDDLARG RSTFMVEMVE
     TAAILNQAGE HSLVILDEIG RGTATFDGLS IAWAAVEYLH EKNRCRALFA THFHEMTALS
     EKLERLSNVT MRVKEWDNDV IFLHEVAKGA ADRSYGVQVA RLAGLPEAVV NRARDVLHQL
     EAGETSGKAD RLIDDLPLFS VMLQQEKPKP QIQAKDSELA NAVAAISPDE LTPREALDLI
     YKLKELAGKA