ID   MUTS_BRUME              Reviewed;         910 AA.
AC   Q8YES6;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BMEI1801;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL52982.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE008917; AAL52982.1; ALT_INIT; Genomic_DNA.
DR   PIR; AC3477; AC3477.
DR   RefSeq; WP_004684675.1; NZ_GG703778.1.
DR   AlphaFoldDB; Q8YES6; -.
DR   SMR; Q8YES6; -.
DR   STRING; 224914.BMEI1801; -.
DR   EnsemblBacteria; AAL52982; AAL52982; BMEI1801.
DR   GeneID; 29594684; -.
DR   KEGG; bme:BMEI1801; -.
DR   PATRIC; fig|224914.52.peg.1781; -.
DR   eggNOG; COG0249; Bacteria.
DR   OMA; TPMMAQY; -.
DR   PhylomeDB; Q8YES6; -.
DR   Proteomes; UP000000419; Chromosome I.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..910
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115077"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         658..665
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   910 AA;  98808 MW;  31DA2659E7E29633 CRC64;
     MEAKVEEKEP EPVENAGPDA PVRLTPMMEQ YIEIKAANVD SLLFYRMGDF YELFFDDAVA
     ASAALGITLT KRGKHLGEDI PMCGVPVHAA DDYLQKLIAK GYRVAVCEQV EDPAEAKKRG
     SKSVVKRDVI RLVTPGTLTE EKLLDPAQAN FLMAMGRTRG DGALALAWID ISTGTFRVAE
     TTPDRLFADI MRVDPRELVV ADSAFHDEEL RPVFDLIGKA VTPQPATLFD SAAAQTRIQH
     YFNVATLDGF GQFSRPELSA ISGAIAYIEK TQISERPPLM RPEREHEGGT LFIDPATRAS
     LELARTMSGN RDGSLLKAID RTVTGGGARL LAERLTAPLT SPKEIALRLD SVSWCLSEQT
     LCEALRLELK GVPDMPRALS RLAVGRGGPR DLGALACGFE AAGGIASLLD GALLPDELAA
     AREAIEKMPA GFAAHLDRAL ADELPLLKRD GGFVREGYNS ELDEMRALRD QSRRVIAGLQ
     ADYIEETGIK SLKIKHNNVL GYFIEVTANN SGAMTDTDEA KSRFIHRQTM ANAMRFTTTE
     LAELESKIAN AADRALSIEL AIFEELTAEA VAHADSIRAA ASALSVFDVS TALAVLAEEQ
     GYCRPHVDDS LSFNIVAGRH PVVEQALRRQ AANPFVANDC DLSPQRDGGD GAIWLLTGPN
     MGGKSTFLRQ NALIAILAQM GSFVPAGSAH IGVVDRLFSR VGASDDLARG RSTFMVEMVE
     TAAILNQAGE HSLVILDEIG RGTATFDGLS IAWAAVEYLH EKNRCRALFA THFHEMTALS
     EKLERLSNVT MRVKEWDNDV IFLHEVAKGA ADRSYGVQVA RLAGLPEAVV NRARDVLHQL
     EAGETSGKAD RLIDDLPLFS VMLQQEKPKP QIQAKDSELA NAVAAISPDE LTPREALDLI
     YKLKELAGKA